1F29
CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I)
Summary for 1F29
Entry DOI | 10.2210/pdb1f29/pdb |
Related | 1AIM 1EWL 1EWM 1EWO 1EWP 1F2A 1F2B 1F2C 2AIM |
Descriptor | CRUZAIN, 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE (3 entities in total) |
Functional Keywords | cysteine protease, covalent inhibitor, vinyl sulfone derived, p1' pocket, hydrolase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 3 |
Total formula weight | 69836.52 |
Authors | Brinen, L.S.,Hansell, E.,Roush, W.R.,McKerrow, J.H.,Fletterick, R.J. (deposition date: 2000-05-23, release date: 2000-07-26, Last modification date: 2011-07-13) |
Primary citation | Brinen, L.S.,Hansell, E.,Cheng, J.,Roush, W.R.,McKerrow, J.H.,Fletterick, R.J. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8:831-840, 2000 Cited by PubMed: 10997902DOI: 10.1016/S0969-2126(00)00173-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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