1EWP

CRUZAIN BOUND TO MOR-LEU-HPQ

Summary for 1EWP

• Entry DOI: 10.2210/pdb1ewp/pdb
• Related: 1aim 1ewl 1ewm 1ewo 2aim
• Related PRD ID: PRD_000312
• Descriptor: CRUZAIN, N-[(3S)-1-fluoro-2-oxo-5-phenylpentan-3-yl]-N~2~-(morpholin-4-ylcarbonyl)-L-leucinamide (3 entities in total)
• Functional Keywords: cysteine protease, drug design, covalent inhibitor, cruzipain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 1
• Total formula weight: 23136.64

Authors

Gillmor, S.A. (deposition date: 2000-04-26, release date: 2000-05-17, Last modification date: 2024-03-13)

• Primary citation: Gillmor, S.A.; Chapter 3: X-ray Structures of Complexes of Cruzain with Designed Covalent Inhibitors; Enzyme-ligand Interactions, Inhibition and Specificity, :50-80, 1998

Experimental method

X-RAY DIFFRACTION (1.75 Å)