PDB: 454 件ウェブページステータス検索Chemie searchBIRD

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1O0E	1.9 Angstrom Crystal Structure of a plant cysteine protease Ervatamin C 分子名称: Ervatamin C, THIOSULFATE 著者 Thakurta, P.G, Chakrabarti, C, Biswas, S, Dattagupta, J.K. 登録日 2003-02-21 公開日 2004-03-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of the Unusual Stability and Substrate Specificity of Ervatamin C, a Plant Cysteine Protease from Ervatamia coronaria Biochemistry, 43, 2004
1QDQ	X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX 分子名称: CATHEPSIN B, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE 著者 Yamamoto, A. 登録日 1999-07-10 公開日 2000-07-10 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex. J.Biochem.(Tokyo), 127, 2000
1Q6K	Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate 分子名称: Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE 著者 Catalano, J.G, Deaton, D.N, Furfine, E.S, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Willard, D.H, Wright, L.L. 登録日 2003-08-13 公開日 2004-03-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Exploration of the P1 SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1PIP	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS 分子名称: Papain, SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE 著者 Yamamoto, A, Tomoo, K, Doi, M, Ohishi, H, Inoue, M, Ishida, T, Yamamoto, D, Tsuboi, S, Okamoto, H, Okada, Y. 登録日 1992-10-03 公開日 1993-10-31 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors. Biochemistry, 31, 1992
1PPD	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS 分子名称: 2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL 著者 Jansonius, J.N. 登録日 1984-11-06 公開日 1985-01-02 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984
1POP	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX 分子名称: LEUPEPTIN, METHANOL, PAPAIN 著者 Schroder, E, Crawford, C. 登録日 1993-06-24 公開日 1993-10-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett., 315, 1993
2DC6	X-ray crystal structure analysis of bovine spleen cathepsin B-CA073 complex 分子名称: BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE, GLYCEROL, PHOSPHATE ION, ... 著者 Watanabe, D. 登録日 2005-12-28 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DC7	X-ray crystal structure analysis of bovine spleen cathepsin B-CA042 complex 分子名称: CATHEPSIN B, GLYCEROL, N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-THREONYL-L-ISOLEUCINE, ... 著者 Watanabe, D. 登録日 2005-12-31 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DCC	X-ray crystal structure analysis of bovine spleen cathepsin B-CA077 complex 分子名称: BENZYL N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE, CATHEPSIN B, GLYCEROL, ... 著者 Watanabe, D. 登録日 2006-01-01 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DCD	X-ray crystal structure analysis of bovine spleen cathepsin B-CA078 complex 分子名称: CATHEPSIN B, GLYCEROL, N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE, ... 著者 Watanabe, D. 登録日 2006-01-01 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DCB	X-ray crystal structure analysis of bovine spleen cathepsin B-CA076 complex 分子名称: CATHEPSIN B, GLYCEROL, N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE, ... 著者 Watanabe, D. 登録日 2006-01-01 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DCA	X-ray crystal structure analysis of bovine spleen cathepsin B-CA075 complex 分子名称: CATHEPSIN B, GLYCEROL, N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE, ... 著者 Watanabe, D. 登録日 2006-01-01 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DC9	X-ray crystal structure analysis of bovine spleen cathepsin B-CA074Me complex 分子名称: CATHEPSIN B, GLYCEROL, METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE, ... 著者 Watanabe, D. 登録日 2005-12-31 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2DC8	X-ray crystal structure analysis of bovine spleen cathepsin B-CA059 complex 分子名称: CATHEPSIN B, GLYCEROL, N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE, ... 著者 Watanabe, D. 登録日 2005-12-31 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes To be Published
2AIM	CRUZAIN INHIBITED WITH BENZOYL-ARGININE-ALANINE-FLUOROMETHYLKETONE 分子名称: BENZOYL-ARGININE-ALANINE-FLUORO-METHYL KETONE, CRUZAIN 著者 Gillmor, S.A, Fletterick, R.J. 登録日 1997-04-21 公開日 1997-10-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural determinants of specificity in the cysteine protease cruzain. Protein Sci., 6, 1997
2BDL	Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor 分子名称: (3S)-1-{[(3,5-DIMETHYLISOXAZOL-4-YL)AMINO]CARBONYL}-4,4-DIMETHYLPYRROLIDIN-3-YL{(1S)-1-[1-HYDROXY-2-OXO-2-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL]PENTYL}CARBAMATE, Cathepsin K 著者 Shewchuk, L.M. 登録日 2005-10-20 公開日 2006-03-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2BDZ	Mexicain from Jacaratia mexicana 分子名称: Mexicain, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE 著者 Gavira, J.A, Oliver-Salvador, M.C, Gonzalez-Ramirez, L.A, Soriano-Garcia, M, Garcia-Ruiz, J.M. 登録日 2005-10-21 公開日 2006-10-03 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic structure of Mexicain from Jacaratia mexicana To be Published
2AS8	Crystal structure of mature and fully active Der p 1 allergen 分子名称: MAGNESIUM ION, Major mite fecal allergen Der p 1 著者 de Halleux, S, Stura, E, VanderElst, L, Carlier, V, Jacquemin, M, Saint-Remy, J.-M. 登録日 2005-08-23 公開日 2005-12-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen J.Allergy Clin.Immunol., 117, 2006
2AUX	Cathepsin K complexed with a semicarbazone inhibitor 分子名称: (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE, Cathepsin K 著者 Adkison, K.K, Barrett, D.G, Deaton, D.N, Gampe, R.T, Hassell, A.M, Long, S.T, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M. 登録日 2005-08-29 公開日 2006-08-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg.Med.Chem.Lett., 16, 2006
2B1M	Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus 分子名称: DI(HYDROXYETHYL)ETHER, SPE31, TETRAETHYLENE GLYCOL, ... 著者 Zhang, M, Wei, Z, Chang, S. 登録日 2005-09-16 公開日 2006-10-03 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a papain-fold protein without the catalytic residue: a novel member in the cysteine proteinase family J.Mol.Biol., 358, 2006
2AUZ	Cathepsin K complexed with a semicarbazone inhibitor 分子名称: 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE, Cathepsin K, SULFATE ION 著者 Adkison, K.K, Barrett, D.G, Deaton, D.N, Gampe, R.T, Hassell, A.M, Long, S.T, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M. 登録日 2005-08-29 公開日 2006-08-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg.Med.Chem.Lett., 16, 2006
2F7D	A mutant rabbit cathepsin K with a nitrile inhibitor 分子名称: (1R,2R)-N-(2-AMINOETHYL)-2-{[(4-METHOXYPHENYL)SULFONYL]METHYL}CYCLOHEXANECARBOXAMIDE, Cathepsin K 著者 Somoza, J.R. 登録日 2005-11-30 公開日 2006-03-07 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J.Med.Chem., 49, 2006
2F1G	Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide 分子名称: Cathepsin S, GLYCEROL, N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE 著者 Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K. 登録日 2005-11-14 公開日 2006-04-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3. Bioorg.Med.Chem.Lett., 16, 2006
5QC3	Crystal structure of human Cathepsin-S with bound ligand 分子名称: 1-{3-[3-{[2-(4-fluoropiperidin-1-yl)ethyl]sulfanyl}-4-(trifluoromethyl)phenyl]-1-[(2S)-2-hydroxy-3-(piperidin-1-yl)propyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}-2-hydroxyethan-1-one, Cathepsin S 著者 Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. 登録日 2017-08-04 公開日 2017-12-20 最終更新日 2021-11-17 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Crystal structure of human Cathepsin-S with bound ligand To be published
5QCJ	Crystal structure of human Cathepsin-S with bound ligand 分子名称: 5-hydroxy-3-{1-[(2S)-2-hydroxy-3-{5-(methylsulfonyl)-3-[4-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl}propyl]piperidin-4-yl}-1H-pyrrolo[3,2-c]pyridin-5-ium, Cathepsin S, SULFATE ION 著者 Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. 登録日 2017-08-04 公開日 2017-12-20 最終更新日 2021-11-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of human Cathepsin-S with bound ligand To be published

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