2BDL

Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor

Summary for 2BDL

Entry DOI	10.2210/pdb2bdl/pdb
Descriptor	Cathepsin K, (3S)-1-{[(3,5-DIMETHYLISOXAZOL-4-YL)AMINO]CARBONYL}-4,4-DIMETHYLPYRROLIDIN-3-YL{(1S)-1-[1-HYDROXY-2-OXO-2-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL]PENTYL}CARBAMATE (3 entities in total)
Functional Keywords	cathepsin, cysteine protease, catk, cato, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	24067.13
Authors	Shewchuk, L.M. (deposition date: 2005-10-20, release date: 2006-03-21, Last modification date: 2023-08-23)
Primary citation	Barrett, D.G.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Long, S.T.,Miller, A.B.,Miller, L.R.,Ray, J.A.,Samano, V.,Shewchuk, L.M.,Wells-Knecht, K.J.,Willard Jr., D.H.,Wright, L.L. Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 16:1735-1739, 2006 Cited by PubMed: 16376075 DOI: 10.1016/j.bmcl.2005.11.101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation