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PDB: 174 results

6R5M
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BU of 6r5m by Molmil
Crystal structure of toxin MT9 from mamba venom
Descriptor: ACETYL GROUP, Dendroaspis polylepis MT9, GLYCEROL, ...
Authors:Stura, E.A, Tepshi, L, Ciolek, J, Triquigneaux, M, Zoukimian, C, De Waard, M, Beroud, R, Servent, D, Gilles, N, Legrand, P, Ciccone, L.
Deposit date:2019-03-25
Release date:2020-02-12
Last modified:2022-05-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries
Biomed Pharmacother, 150, 2022
4WZV
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Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain
Descriptor: (2R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxy-2-{[(4'-methoxybiphenyl-4-yl)sulfonyl](propan-2-yloxy)amino}butanamide, 1,2-ETHANEDIOL, AZIDE ION, ...
Authors:Stura, E.A, Vera, L, Cassar-Lajeunesse, E, Nuti, E, Dive, V, Rossello, A.
Deposit date:2014-11-20
Release date:2015-08-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
J.Med.Chem., 58, 2015
4XCT
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Crystal structure of a hydroxamate based inhibitor ARP101 (EN73) in complex with the MMP-9 catalytic domain.
Descriptor: (2S,3S)-butane-2,3-diol, (2~{R})-3-methyl-~{N}-oxidanylidene-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxy-amino]butanamide, 1,2-ETHANEDIOL, ...
Authors:Stura, E.A, Tepshi, L, Nuti, E, Dive, V, Cassar-Lajeunesse, E, Vera, L, Rossello, A.
Deposit date:2014-12-18
Release date:2015-04-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
J.Med.Chem., 58, 2015
4TQI
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BU of 4tqi by Molmil
Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode
Descriptor: (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, Transthyretin
Authors:Stura, E.A, Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E.
Deposit date:2014-06-11
Release date:2015-06-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.
J Enzyme Inhib Med Chem, 2015
3LJG
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BU of 3ljg by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: ACETOHYDROXAMIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ...
Authors:Stura, E.A, Dive, V, Devel, L, Vera, L, Beau, F.
Deposit date:2010-01-26
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.313 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIR
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BU of 3lir by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: CALCIUM ION, GLYCINE, Macrophage metalloelastase, ...
Authors:Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIL
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BU of 3lil by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: ACETOHYDROXAMIC ACID, CALCIUM ION, Macrophage metalloelastase, ...
Authors:Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3FEV
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BU of 3fev by Molmil
Crystal structure of the chimeric muscarinic toxin MT7 with loop 1 from MT1.
Descriptor: Fusion of Muscarinic toxin 1, Muscarinic m1-toxin1, SULFATE ION
Authors:Stura, E.A, Menez, R, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D.
Deposit date:2008-12-01
Release date:2009-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
5I0L
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Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (DC27).
Descriptor: (2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid, 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A.
Deposit date:2016-02-04
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
Chemmedchem, 11, 2016
3F5V
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C2 Crystal form of mite allergen DER P 1
Descriptor: CALCIUM ION, Der p 1 allergen, HEXAETHYLENE GLYCOL
Authors:Stura, E.A, Minor, W, Chruszcz, M, Saint Remy, J.M.
Deposit date:2008-11-04
Release date:2009-02-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding.
J.Mol.Biol., 386, 2009
5I12
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BU of 5i12 by Molmil
Crystal structure of the catalytic domain of MMP-9 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (DC27).
Descriptor: (2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid, 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A.
Deposit date:2016-02-05
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
Chemmedchem, 11, 2016
5I3M
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BU of 5i3m by Molmil
Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated thiourea-linked carboxylate zinc-chelator water-soluble inhibitor (DC31).
Descriptor: (2S)-2-{[2-({[(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]carbamothioyl}amino)ethyl](biphenyl-4-ylsulfonyl)amino}-3-methylbutanoic acid (non-preferred name), 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, ...
Authors:Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
Chemmedchem, 11, 2016
5I4O
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BU of 5i4o by Molmil
Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate zinc-chelator water-soluble inhibitor (DC28).
Descriptor: CALCIUM ION, Macrophage metalloelastase, N-({1-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-1H-1,2,3-triazol-4-yl}methyl)-N-[([1,1'-biphenyl]-4-yl)sulfonyl]-D-valine, ...
Authors:Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A.
Deposit date:2016-02-12
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
Chemmedchem, 11, 2016
5I2Z
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BU of 5i2z by Molmil
Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelating water-soluble inhibitor (DC24).
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A.
Deposit date:2016-02-09
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
Chemmedchem, 11, 2016
5I43
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BU of 5i43 by Molmil
Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelator water-soluble inhibitor (DC32).
Descriptor: (2R)-2-[({1-[3-({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}oxy)propyl]-1H-1,2,3-triazol-4-yl}methyl)(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid (non-preferred name), 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A.
Deposit date:2016-02-11
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
Chemmedchem, 11, 2016
3LIK
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BU of 3lik by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: ACETOHYDROXAMIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ...
Authors:Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
5M4V
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BU of 5m4v by Molmil
X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor
Descriptor: CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL
Authors:Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N.
Deposit date:2016-10-19
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5K1N
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BU of 5k1n by Molmil
Human TTR altered by a rhenium tris-carbonyl Pyta-C12 derivative
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Stura, E.A, Ciccone, L, Shepard, W.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Human TTR conformation altered by rhenium tris-carbonyl derivatives.
J.Struct.Biol., 195, 2016
3NDS
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BU of 3nds by Molmil
Crystal structure of engineered Naja Nigricollis toxin alpha
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION, Short neurotoxin 1
Authors:Stura, E.A, Drevet, P, Gregory, G, Gallopin, M, Vandame, M.
Deposit date:2010-06-08
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Conformational exchange is critical for the productivity of an oxidative folding intermediate with buried free cysteines.
J.Mol.Biol., 403, 2010
5DO6
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BU of 5do6 by Molmil
Crystal structure of Dendroaspis polylepis venom mambalgin-1 T23A mutant
Descriptor: 1,2-ETHANEDIOL, IODIDE ION, Mambalgin-1, ...
Authors:Stura, E.A, Tepshi, L, Kessler, P, Gilles, M, Servent, D.
Deposit date:2015-09-10
Release date:2015-12-30
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
J.Biol.Chem., 291, 2016
3QUM
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BU of 3qum by Molmil
Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody
Descriptor: Fab 5D3D11 Heavy Chain, Fab 5D3D11 Light Chain, Fab 5D5A5 Heavy Chain, ...
Authors:Stura, E.A, Muller, B.H, Michel, S, Ducancel, F.
Deposit date:2011-02-24
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of human prostate-specific antigen in a sandwich antibody complex.
J.Mol.Biol., 414, 2011
5K1J
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BU of 5k1j by Molmil
Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ...
Authors:Stura, E.A, Ciccone, L, Shepard, W.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Human TTR conformation altered by rhenium tris-carbonyl derivatives.
J.Struct.Biol., 195, 2016
5MG9
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BU of 5mg9 by Molmil
Putative Ancestral Mamba toxin 1 (AncTx1-W28R/I38S)
Descriptor: 1,2-ETHANEDIOL, AncTx1-W28R/I38S, S-1,2-PROPANEDIOL, ...
Authors:Stura, E.A, Tepshi, L, Blanchet, G, Mourier, G, Servent, D.
Deposit date:2016-11-21
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins.
Sci Rep, 7, 2017
4KS6
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BU of 4ks6 by Molmil
Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 166-174 stretch
Descriptor: 1,2-ETHANEDIOL, Botulinum neurotoxin A light chain, DI(HYDROXYETHYL)ETHER, ...
Authors:Stura, E.A, Vera, L, Guitot, K, Dive, V.
Deposit date:2013-05-17
Release date:2014-06-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
To be Published
4KUF
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BU of 4kuf by Molmil
Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134 mutant with MTSEA modified Cys-165 causing stretch disorder
Descriptor: (2S)-2-hydroxybutanedioic acid, 1,2-ETHANEDIOL, Botulinum neurotoxin A light chain, ...
Authors:Stura, E.A, Vera, L, Ptchelkine, D, Bakirci, H, Garcia, S, Dive, V.
Deposit date:2013-05-22
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
To be Published

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