5I0L
Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (DC27).
Summary for 5I0L
Entry DOI | 10.2210/pdb5i0l/pdb |
Related | 4H30 4H84 |
Descriptor | Macrophage metalloelastase, (2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid, ZINC ION, ... (9 entities in total) |
Functional Keywords | inhibitor, complex, glycoconjugate, metalloprotease, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 2 |
Total formula weight | 37705.69 |
Authors | Stura, E.A.,Rosalia, L.,Cuffaro, D.,Tepshi, L.,Ciccone, L.,Rossello, A. (deposition date: 2016-02-04, release date: 2016-07-06, Last modification date: 2024-01-10) |
Primary citation | Nuti, E.,Cuffaro, D.,D'Andrea, F.,Rosalia, L.,Tepshi, L.,Fabbi, M.,Carbotti, G.,Ferrini, S.,Santamaria, S.,Camodeca, C.,Ciccone, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Dive, V.,Rossello, A. Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors. Chemmedchem, 11:1626-1637, 2016 Cited by PubMed: 27356908DOI: 10.1002/cmdc.201600235 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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