4H30
Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.
Summary for 4H30
Entry DOI | 10.2210/pdb4h30/pdb |
Related | 3LIR 4EFS 4H1Q 4H2E 4H3X |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | divalent inhibitor, carboxylic twin inhibitor, dimerisation, metzincin, zinc protease, hydrolase-hydrolase inhibtior complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 2 |
Total formula weight | 37459.36 |
Authors | Antoni, C.,Stura, E.A.,Vera, L.,Nuti, E.,Carafa, L.,Cassar-Lajeunesse, E.,Dive, V.,Rossello, A. (deposition date: 2012-09-13, release date: 2013-04-24, Last modification date: 2023-09-20) |
Primary citation | Antoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A. Crystallization of bi-functional ligand protein complexes. J.Struct.Biol., 182:246-254, 2013 Cited by PubMed: 23567804DOI: 10.1016/j.jsb.2013.03.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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