Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS218 |
| A | HIS222 |
| A | HIS228 |
| B | 0ZD306 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS168 |
| A | ASP170 |
| A | HIS183 |
| A | HIS196 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | GLY190 |
| A | GLY192 |
| A | ASP194 |
| A | HOH416 |
| A | HOH424 |
| A | ASP158 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP124 |
| A | GLU199 |
| A | GLU201 |
| A | HOH404 |
| A | HOH405 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ASP175 |
| A | GLY176 |
| A | GLY178 |
| A | ILE180 |
| A | ASP198 |
| A | GLU201 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 306 |
| Chain | Residue |
| A | VAL144 |
| A | THR145 |
| A | PRO146 |
| A | LYS151 |
| A | ASN153 |
| A | GLN259 |
| A | HOH437 |
| A | HOH498 |
| A | HOH538 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 307 |
| Chain | Residue |
| A | ASP170 |
| A | HIS172 |
| A | PHE185 |
| A | ILE191 |
| B | SER207 |
| B | GLY208 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 308 |
| Chain | Residue |
| A | TYR132 |
| A | LYS136 |
| A | PHE213 |
| A | ILE245 |
| A | HOH532 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 309 |
| Chain | Residue |
| A | VAL108 |
| A | TRP109 |
| A | ARG110 |
| A | GLY188 |
| A | SER189 |
| A | HOH490 |
| A | HOH536 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 310 |
| Chain | Residue |
| A | PRO232 |
| A | ALA234 |
| A | VAL235 |
| A | LYS241 |
| A | VAL243 |
| A | HOH501 |
| A | HOH503 |
| A | HOH568 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 311 |
| Chain | Residue |
| A | HIS172 |
| A | ALA184 |
| A | PHE185 |
| A | HOH435 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS218 |
| B | HIS222 |
| B | HIS228 |
| B | 0ZD306 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS168 |
| B | ASP170 |
| B | HIS183 |
| B | HIS196 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| A | ARG110 |
| B | ASP158 |
| B | GLY190 |
| B | GLY192 |
| B | ASP194 |
| B | HOH442 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP124 |
| B | GLU199 |
| B | GLU201 |
| B | HOH407 |
| B | HOH408 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 305 |
| Chain | Residue |
| B | ASP175 |
| B | GLY176 |
| B | GLY178 |
| B | ILE180 |
| B | ASP198 |
| B | GLU201 |
| site_id | BC8 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE 0ZD B 306 |
| Chain | Residue |
| A | PHE237 |
| A | PRO238 |
| A | THR239 |
| A | TYR240 |
| A | ZN301 |
| A | HOH401 |
| A | HOH433 |
| B | ILE180 |
| B | LEU181 |
| B | ALA182 |
| B | LEU214 |
| B | THR215 |
| B | HIS218 |
| B | GLU219 |
| B | HIS222 |
| B | HIS228 |
| B | VAL235 |
| B | PHE237 |
| B | PRO238 |
| B | THR239 |
| B | TYR240 |
| B | ZN301 |
| B | GOL308 |
| B | HOH438 |
| B | HOH449 |
| B | HOH451 |
| B | HOH472 |
| B | HOH514 |
| A | ILE180 |
| A | LEU181 |
| A | ALA182 |
| A | LEU214 |
| A | THR215 |
| A | HIS218 |
| A | GLU219 |
| A | HIS222 |
| A | HIS228 |
| A | VAL235 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 307 |
| Chain | Residue |
| B | MET105 |
| B | GLY225 |
| B | LEU226 |
| B | GLY227 |
| B | GLY257 |
| B | SER260 |
| B | LEU261 |
| B | HOH532 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 308 |
| Chain | Residue |
| B | SER229 |
| B | SER230 |
| B | PRO238 |
| B | 0ZD306 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG B 309 |
| Chain | Residue |
| B | ASP171 |
| B | HIS172 |
| B | HOH467 |
| B | HOH468 |
| B | HOH550 |
| B | HOH585 |
| B | HOH610 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL |
| Chain | Residue | Details |
| A | THR215-LEU224 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU219 | |
| B | GLU219 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP175 | |
| A | GLY176 | |
| A | GLY178 | |
| A | ILE180 | |
| A | HIS183 | |
| A | GLY190 | |
| A | GLY192 | |
| A | ASP194 | |
| A | HIS196 | |
| A | ASP198 | |
| A | GLU199 | |
| A | GLU201 | |
| A | HIS218 | |
| A | HIS222 | |
| A | HIS228 | |
| B | ASP124 | |
| B | ASP158 | |
| B | HIS168 | |
| B | ASP170 | |
| B | ASP175 | |
| B | GLY176 | |
| B | GLY178 | |
| B | ILE180 | |
| B | HIS183 | |
| B | GLY190 | |
| B | GLY192 | |
| B | ASP194 | |
| B | HIS196 | |
| B | ASP198 | |
| B | GLU199 | |
| B | GLU201 | |
| B | HIS218 | |
| B | HIS222 | |
| B | HIS228 | |
| A | HIS168 | |
| A | ASP124 | |
| A | ASP158 | |
| A | ASP170 | |
