5M4V

X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor

Summary for 5M4V

Entry DOI	10.2210/pdb5m4v/pdb
Descriptor	Mambaquaretin-1, S-1,2-PROPANEDIOL, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	vasopressin antagonist, mamba venom, kunitz, toxin
Biological source	Dendroaspis angusticeps (eastern green mamba)
Total number of polymer chains	1
Total formula weight	6563.42
Authors	Stura, E.A.,Vera, L.,Ciolek, J.,Mourier, G.,Gilles, N. (deposition date: 2016-10-19, release date: 2017-05-03, Last modification date: 2024-01-17)
Primary citation	Ciolek, J.,Reinfrank, H.,Quinton, L.,Viengchareun, S.,Stura, E.A.,Vera, L.,Sigismeau, S.,Mouillac, B.,Orcel, H.,Peigneur, S.,Tytgat, J.,Droctove, L.,Beau, F.,Nevoux, J.,Lombes, M.,Mourier, G.,De Pauw, E.,Servent, D.,Mendre, C.,Witzgall, R.,Gilles, N. Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc. Natl. Acad. Sci. U.S.A., 114:7154-7159, 2017 Cited by PubMed: 28630289 DOI: 10.1073/pnas.1620454114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.06 Å)

Structure validation