2AUX

Cathepsin K complexed with a semicarbazone inhibitor

Summary for 2AUX

• Entry DOI: 10.2210/pdb2aux/pdb
• Related: 2AUZ
• Descriptor: Cathepsin K, (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE (3 entities in total)
• Functional Keywords: catk, cysteine protease, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P43235
• Total number of polymer chains: 1
• Total formula weight: 23828.89

Authors

Adkison, K.K.,Barrett, D.G.,Deaton, D.N.,Gampe, R.T.,Hassell, A.M.,Long, S.T.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M. (deposition date: 2005-08-29, release date: 2006-08-08, Last modification date: 2023-08-23)

• Primary citation: Adkison, K.K.,Barrett, D.G.,Deaton, D.N.,Gampe, R.T.,Hassell, A.M.,Long, S.T.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Shewchuk, L.M.,Wells-Knecht, K.J.,Willard, D.H.,Wright, L.L.; Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?; Bioorg.Med.Chem.Lett., 16:978-983, 2006; PubMed: 16290936; DOI: 10.1016/j.bmcl.2005.10.108

Experimental method

X-RAY DIFFRACTION (2.4 Å)