PDB: 242 件ウェブページステータス検索Chemie searchBIRD

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1D3G	HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG 分子名称: 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... 著者 Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J. 登録日 1999-09-29 公開日 2000-09-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure Fold.Des., 8, 2000
1D3H	HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726 分子名称: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... 著者 Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J. 登録日 1999-09-29 公開日 2000-08-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure Fold.Des., 8, 2000
1DOR	DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS 分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE 著者 Rowland, P, Larsen, S. 登録日 1997-01-14 公開日 1997-04-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis. Structure, 5, 1997
1EP1	CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B 分子名称: DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FE2/S2 (INORGANIC) CLUSTER, ... 著者 Rowland, P, Norager, S, Jensen, K.F, Larsen, S. 登録日 2000-03-27 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster. Structure Fold.Des., 8, 2000
1EP2	CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B COMPLEXED WITH OROTATE 分子名称: DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FE2/S2 (INORGANIC) CLUSTER, ... 著者 Rowland, P, Norager, S, Jensen, K.F, Larsen, S. 登録日 2000-03-27 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster. Structure Fold.Des., 8, 2000
1EP3	CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B. DATA COLLECTED UNDER CRYOGENIC CONDITIONS. 分子名称: DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FE2/S2 (INORGANIC) CLUSTER, ... 著者 Rowland, P, Norager, S, Jensen, K.F, Larsen, S. 登録日 2000-03-27 公開日 2001-01-17 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster. Structure Fold.Des., 8, 2000
1F76	ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE 分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ... 著者 Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S. 登録日 2000-06-26 公開日 2002-10-16 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases Structure, 10, 2002
1GT8	DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID 分子名称: DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2002-01-14 公開日 2002-04-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002
1GTE	DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, BINARY COMPLEX WITH 5-IODOURACIL 分子名称: 5-IODOURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2002-01-15 公開日 2002-04-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002
1GTH	DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND 5-IODOURACIL 分子名称: (5S)-5-IODODIHYDRO-2,4(1H,3H)-PYRIMIDINEDIONE, 5-IODOURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, ... 著者 Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2002-01-15 公開日 2002-04-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002
1H7W	Dihydropyrimidine dehydrogenase (DPD) from pig 分子名称: DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Dobritzsch, D, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2001-01-19 公開日 2001-02-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil. EMBO J., 20, 2001
1H7X	Dihydropyrimidine dehydrogenase (DPD) from pig, ternary complex of a mutant enzyme (C671A), NADPH and 5-fluorouracil 分子名称: 5-FLUOROURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Dobritzsch, D, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2001-01-19 公開日 2001-02-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil Embo J., 20, 2001
1JQV	The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A 分子名称: ACETIC ACID, Dihydroorotate dehydrogenase A, FLAVIN MONONUCLEOTIDE, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-09 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JQX	The R57A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-09 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JRB	The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-13 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JRC	The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-13 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JUB	The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-24 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JUE	1.8 A resolution structure of native lactococcus lactis dihydroorotate dehydrogenase A 分子名称: ACETIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-24 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1OVD	THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A IN COMPLEX WITH OROTATE 分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2003-03-26 公開日 2003-08-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. J.Biol.Chem., 278, 2003
1TV5	Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor 分子名称: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Dihydroorotate dehydrogenase homolog, ... 著者 Hurt, D.E, Widom, J, Clardy, J. 登録日 2004-06-27 公開日 2005-09-06 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystallogr.,Sect.D, 62, 2006
1UUM	Rat dihydroorotate dehydrogenase (DHOD)in complex with atovaquone 分子名称: 2-[4-(4-CHLOROPHENYL)CYCLOHEXYLIDENE]-3,4-DIHYDROXY-1(2H)-NAPHTHALENONE, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Hansen, M, Le Nours, J, Johansson, E, Antal, T, Ullrich, A, Loffler, M, Larsen, S. 登録日 2004-01-06 公開日 2004-04-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain Protein Sci., 13, 2004
1UUO	Rat dihydroorotate dehydrogenase (DHOD)in complex with brequinar 分子名称: 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Hansen, M, Le Nours, J, Johansson, E, Antal, T, Ullrich, A, Loffler, M, Larsen, S. 登録日 2004-01-08 公開日 2004-04-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain Protein Sci., 13, 2004
2B0M	Human dihydroorotate dehydrogenase bound to a novel inhibitor 分子名称: 3-AMIDO-5-BIPHENYL-BENZOIC ACID, Dihydroorotate dehydrogenase, mitochondrial, ... 著者 Hurt, D.E, Sutton, A.E, Clardy, J. 登録日 2005-09-14 公開日 2005-09-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg.Med.Chem.Lett., 16, 2006
2B4G	dihydroorotate dehydrogenase 分子名称: BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2005-09-23 公開日 2005-10-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies Mol.Microbiol., 68, 2008
2BSL	Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,4-dihydroxybenzoate 分子名称: 3,4-DIHYDROXYBENZOIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE A, ... 著者 Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A. 登録日 2005-05-23 公開日 2006-08-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis. Biochemistry, 46, 2007

 

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