1H7X

Dihydropyrimidine dehydrogenase (DPD) from pig, ternary complex of a mutant enzyme (C671A), NADPH and 5-fluorouracil

Summary for 1H7X

Entry DOI	10.2210/pdb1h7x/pdb
Related	1H7W
Descriptor	DIHYDROPYRIMIDINE DEHYDROGENASE, IRON/SULFUR CLUSTER, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
Functional Keywords	electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase
Biological source	SUS SCROFA (WILD BOAR)
Cellular location	Cytoplasm: Q28943
Total number of polymer chains	4
Total formula weight	460380.93
Authors	Dobritzsch, D.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y. (deposition date: 2001-01-19, release date: 2001-02-23, Last modification date: 2018-02-07)
Primary citation	Dobritzsch, D.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y. Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil Embo J., 20:650-, 2001 Cited by PubMed: 11179210 DOI: 10.1093/EMBOJ/20.4.650 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation