7Q62
| |
8ENU
| Structure of the C3bB proconvertase in complex with lufaxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2022-09-30 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
|
|
7Q5Z
| |
6YSQ
| The hC4Nb8 complement inhibitory nanobody in complex with C4b | 分子名称: | Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ... | 著者 | Zarantonello, A, Laursen, N.S, Andersen, G.R. | 登録日 | 2020-04-23 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. J Immunol., 205, 2020
|
|
7NYD
| cryoEM structure of 2C9-sMAC | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Menny, A, Couves, E.C, Bubeck, D. | 登録日 | 2021-03-22 | 公開日 | 2021-10-06 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of soluble membrane attack complex packaging for clearance. Nat Commun, 12, 2021
|
|
8B0H
| 2C9, C5b9-CD59 cryoEM structure | 分子名称: | CD59 glycoprotein, Complement C5, Complement component C6, ... | 著者 | Couves, E.C, Gardner, S, Bubeck, D. | 登録日 | 2022-09-07 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
|
|
8B0G
| 2C9, C5b9-CD59 structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ... | 著者 | Couves, E.C, Gardner, S, Bubeck, D. | 登録日 | 2022-09-07 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
|
|
2A73
| Human Complement Component C3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P. | 登録日 | 2005-07-04 | 公開日 | 2005-09-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structures of complement component C3 provide insights into the function and evolution of immunity. Nature, 437, 2005
|
|
5FO9
| Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
|
|
8AYH
| |
7B2M
| Cryo-EM structure of complement C4b in complex with nanobody E3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody E3, Complement C4 alpha chain, ... | 著者 | Oosterheert, W, De la O Becerra, K.I, van den Bos, R.M, Gros, P. | 登録日 | 2020-11-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
|
|
7AKK
| Structure of a complement factor-receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C. | 登録日 | 2020-10-01 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.395 Å) | 主引用文献 | The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor Nat Commun, 13, 2022
|
|
7TV9
| HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, APL-1030 Nanofitin, Complement C3 beta chain, ... | 著者 | Fontano, E, Nadupalli, A, Lakshminarasimhan, D, White, A, Garlish, J, Cinier, M, Chevrel, A, Perrocheau, A, Eyerman, D, Orme, M, Kitten, O, Scheibler, L. | 登録日 | 2022-02-04 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation. Biomolecules, 12, 2022
|
|
8OVB
| |
7B2P
| Cryo-EM structure of complement C4b in complex with nanobody B5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4 alpha chain, ... | 著者 | Oosterheert, W, De la O Becerra, K.I, Gros, P. | 登録日 | 2020-11-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
|
|
2XWB
| Crystal Structure of Complement C3b in complex with Factors B and D | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3B ALPHA' CHAIN, ... | 著者 | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | 登録日 | 2010-11-01 | 公開日 | 2011-01-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
|
|
6RQJ
| Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5, Complement inhibitor, ... | 著者 | Reichhardt, M.P, Johnson, S, Lea, S.M. | 登録日 | 2019-05-15 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | An inhibitor of complement C5 provides structural insights into activation. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5JTW
| |
7NYC
| cryoEM structure of 3C9-sMAC | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Menny, A, Couves, E.C, Bubeck, D. | 登録日 | 2021-03-22 | 公開日 | 2021-10-06 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of soluble membrane attack complex packaging for clearance. Nat Commun, 12, 2021
|
|
4A5W
| Crystal structure of C5b6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... | 著者 | Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. | 登録日 | 2011-10-28 | 公開日 | 2012-03-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9. Cell Rep., 1, 2012
|
|
8EOK
| |
7ZGJ
| |
8UH2
| Complex of C3b with the inhibitor albicin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | 著者 | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | 登録日 | 2023-10-06 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | The mechanism of a mosquito salivary inhibitor of the alternative C3 convertase is elucidated through structural analysis of its complex with C3bBb To Be Published
|
|
7ZGK
| |
5JPN
| Structure of human complement C4 rebuilt using iMDFF | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A, ... | 著者 | Croll, T.I, Andersen, G.R. | 登録日 | 2016-05-03 | 公開日 | 2016-08-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
|
|