6RQJ

Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1

Summary for 6RQJ

Entry DOI	10.2210/pdb6rqj/pdb
Related	6rpt
EMDB information	4983
Descriptor	Complement C5, Complement inhibitor, Rhipicephalus appendiculatus RaCI1, ... (6 entities in total)
Functional Keywords	complement, inhibitor, innate immunity, inflammation, c5, terminal pathway inhibitor, immunosuppressant
Biological source	Rhipicephalus pulchellus More
Total number of polymer chains	5
Total formula weight	225798.83
Authors	Reichhardt, M.P.,Johnson, S.,Lea, S.M. (deposition date: 2019-05-15, release date: 2020-01-08, Last modification date: 2020-07-29)
Primary citation	Reichhardt, M.P.,Johnson, S.,Tang, T.,Morgan, T.,Tebeka, N.,Popitsch, N.,Deme, J.C.,Jore, M.M.,Lea, S.M. An inhibitor of complement C5 provides structural insights into activation. Proc.Natl.Acad.Sci.USA, 117:362-370, 2020 Cited by PubMed: 31871188 DOI: 10.1073/pnas.1909973116 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation