6RQJ

Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Complement C5	polymer	999	112635.0	1	UniProt (P01031) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) Pfam (PF07677) Pfam (PF01759) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
2	C	Complement inhibitor	polymer	165	18647.6	1	UniProt (Q5YD59) In PDB	Rhipicephalus pulchellus
3	D	Rhipicephalus appendiculatus RaCI1	polymer	81	8576.8	1	UniProt (A0A158RFT5) UniProt (by SIFTS) (A0A141SFN4) In PDB	Rhipicephalus pulchellus
4	B	Complement C5	polymer	655	73361.5	1	UniProt (P01031) Pfam (PF17789) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
5	E	Putative 8.9 kDa family member	polymer	112	12153.6	1	UniProt (L7MB58) Pfam (PF15430) In PDB	Rhipicephalus pulchellus
6	F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)

Sequence modifications

C: 19 - 168 (UniProt: Q5YD59)

PDB	External Database	Details
Met 4	-	initiating methionine
Ala 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
Ser 17	-	expression tag
Gly 18	-	expression tag
Gln 78	Asn 78	engineered mutation
Gln 102	Asn 102	engineered mutation

E: 5 - 92 (UniProt: L7MB58)

PDB	External Database	Details
Lys -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ala -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Glu -8	-	expression tag
Val -7	-	expression tag
Leu -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Pro -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag
Asp 1	-	expression tag
Val 2	-	expression tag
Gln 3	-	expression tag
Glu 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	225374.4
Branched	Number of molecules	1
	Total formula weight	424.4
All*	Total formula weight	225798.8

*Water molecules are not included.