6RQJ
Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Complement C5 | polymer | 999 | 112635.0 | 1 | UniProt (P01031) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) Pfam (PF07677) Pfam (PF01759) | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| 2 | B (C) | Complement inhibitor | polymer | 165 | 18647.6 | 1 | UniProt (Q5YD59) | Rhipicephalus pulchellus | |
| 3 | C (D) | Rhipicephalus appendiculatus RaCI1 | polymer | 81 | 8576.8 | 1 | UniProt (A0A158RFT5) UniProt (by SIFTS) (A0A141SFN4) | Rhipicephalus pulchellus | |
| 4 | D (B) | Complement C5 | polymer | 655 | 73361.5 | 1 | UniProt (P01031) Pfam (PF17789) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| 5 | E (E) | Putative 8.9 kDa family member | polymer | 112 | 12153.6 | 1 | UniProt (L7MB58) | Rhipicephalus pulchellus | |
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
C: 19 - 168 (UniProt: Q5YD59)
E: 5 - 92 (UniProt: L7MB58)
| PDB | External Database | Details |
|---|---|---|
| Met 4 | - | initiating methionine |
| Ala 5 | - | expression tag |
| Ser 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Gln 78 | Asn 78 | engineered mutation |
| Gln 102 | Asn 102 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Val -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Val 2 | - | expression tag |
| Gln 3 | - | expression tag |
| Glu 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 225374.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| All* | Total formula weight | 225798.8 |
