7RXG
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7RXB
| afTMEM16 lipid scramblase in C18 lipid nanodiscs in the absence of Ca2+ | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase | Authors: | Feng, Z, Accardi, A. | Deposit date: | 2021-08-22 | Release date: | 2022-05-18 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | TMEM16 scramblases thin the membrane to enable lipid scrambling. Nat Commun, 13, 2022
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7RXA
| afTMEM16 DE/AA mutant in C14 lipid nanodiscs in the presence of Ca2+ | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase | Authors: | Feng, Z, Accardi, A. | Deposit date: | 2021-08-22 | Release date: | 2022-05-18 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | TMEM16 scramblases thin the membrane to enable lipid scrambling. Nat Commun, 13, 2022
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7RX3
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7RX2
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7RWJ
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7B5E
| Structure of calcium-bound mTMEM16A(ac)-I551A chloride channel at 4.1 A resolution | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | Deposit date: | 2020-12-03 | Release date: | 2021-02-10 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Gating the pore of the calcium-activated chloride channel TMEM16A. Nat Commun, 12, 2021
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7B5D
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7B5C
| Structure of calcium-bound mTMEM16A(ac) chloride channel at 3.7 A resolution | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | Deposit date: | 2020-12-03 | Release date: | 2021-02-10 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Gating the pore of the calcium-activated chloride channel TMEM16A. Nat Commun, 12, 2021
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6R7Z
| CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form) | Descriptor: | Anoctamin-10 | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-29 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.14 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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6R7Y
| CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form) | Descriptor: | Anoctamin-10, CALCIUM ION | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-29 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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6R7X
| CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-10, CALCIUM ION, ... | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Baronina, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-29 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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6R65
| Crystal Structure of human TMEM16K / Anoctamin 10 (Form 2) | Descriptor: | Anoctamin-10, CALCIUM ION | Authors: | Bushell, S.R, Pike, A.C.W, Chu, A, Tessitore, A, Rotty, B, Mukhopadhyay, S, Kupinska, K, Shrestha, L, Borkowska, O, Chalk, R, Burgess-Brown, N.A, Love, J, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-26 | Release date: | 2019-05-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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6QPI
| Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc | Descriptor: | Anoctamin-6 | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-14 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QPC
| Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in nanodisc | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QPB
| Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in digitonin | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6 | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QP6
| Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in digitonin | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QMB
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (closed state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QMA
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (intermediate state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QM9
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (open state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QM6
| Cryo-EM structure of calcium-free nhTMEM16 lipid scramblase in DDM | Descriptor: | Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QM5
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in DDM | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QM4
| Cryo-EM structure of calcium-free nhTMEM16 lipid scramblase in nanodisc | Descriptor: | Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6P49
| Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2 | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6P48
| Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1 | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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