6FVB
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6AHO
| Crystal structure of Kap114p | Descriptor: | Importin subunit beta-5 | Authors: | Liao, C.C, Shankar, S, Ahmed, G.R, Hsia, K.C. | Deposit date: | 2018-08-20 | Release date: | 2019-10-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression under saline stress. Embo Rep., 21, 2020
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4XRI
| Crystal Structure of Importin Beta in an Ammonium Sulfate Condition | Descriptor: | GLYCEROL, Putative uncharacterized protein, SULFATE ION | Authors: | Tauchert, M.J, Neumann, P, Ficner, R, Dickmanns, A. | Deposit date: | 2015-01-21 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Impact of the crystallization condition on importin-beta conformation. Acta Crystallogr D Struct Biol, 72, 2016
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4XRK
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3GB8
| Crystal structure of CRM1/Snurportin-1 complex | Descriptor: | Exportin-1, Snurportin-1 | Authors: | Dong, X, Biswas, A, Suel, K.E, Jackson, L.K, Martinez, R, Gu, H, Chook, Y.M. | Deposit date: | 2009-02-19 | Release date: | 2009-03-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for leucine-rich nuclear export signal recognition by CRM1. Nature, 458, 2009
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1GCJ
| N-TERMINAL FRAGMENT OF IMPORTIN-BETA | Descriptor: | IMPORTIN BETA | Authors: | Lee, S.J, Imamoto, N, Sakai, H, Nakagawa, A, Kose, S, Koike, M, Yamamoto, M, Kumasaka, T, Yoneda, Y, Tsukihara, T. | Deposit date: | 2000-07-31 | Release date: | 2000-10-18 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport. J.Mol.Biol., 302, 2000
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4BSN
| Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.1A | Descriptor: | EXPORTIN-1 | Authors: | Dian, C, Bernaudat, F, Langer, K, Oliva, M.F, Fornerod, M, Schoehn, G, Muller, C.W, Petosa, C. | Deposit date: | 2013-06-11 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix. Structure, 21, 2013
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4BSM
| Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.5A | Descriptor: | EXPORTIN-1 | Authors: | Dian, C, Bernaudat, F, Langer, K, Oliva, M.F, Fornerod, M, Schoehn, G, Muller, C.W, Petosa, C. | Deposit date: | 2013-06-10 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix. Structure, 21, 2013
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3VYC
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3ZKV
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5YU7
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7L5E
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7B51
| Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528 | Descriptor: | BETA-MERCAPTOETHANOL, Exportin-1, GTP-binding nuclear protein Ran, ... | Authors: | Shaikhqasem, A, Ficner, R. | Deposit date: | 2020-12-03 | Release date: | 2021-03-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP. Acta Crystallogr.,Sect.F, 77, 2021
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5OWU
| Kap95:Nup1 complex | Descriptor: | Importin subunit beta-1, Nucleoporin NUP1 | Authors: | Stewart, M. | Deposit date: | 2017-09-04 | Release date: | 2017-10-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p. J. Mol. Biol., 349, 2005
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7YPZ
| Zafirlukast in complex with CRM1-Ran-RanBP1 | Descriptor: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-08-05 | Release date: | 2023-08-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
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2BKU
| Kap95p:RanGTP complex | Descriptor: | GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... | Authors: | Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. | Deposit date: | 2005-02-21 | Release date: | 2005-05-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
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1Z3H
| The exportin Cse1 in its cargo-free, cytoplasmic state | Descriptor: | Importin alpha re-exporter, MAGNESIUM ION | Authors: | Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E. | Deposit date: | 2005-03-12 | Release date: | 2005-05-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding Mol.Cell, 18, 2005
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7UNK
| Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex | Descriptor: | Histone H3, Histone H4, Histone chaperone, ... | Authors: | Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y. | Deposit date: | 2022-04-11 | Release date: | 2022-09-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
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1M5N
| Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP | Descriptor: | Importin beta-1 subunit, Parathyroid hormone-related protein | Authors: | Cingolani, G, Bednenko, J, Gillespie, M.T, Gerace, L. | Deposit date: | 2002-07-09 | Release date: | 2003-01-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular basis for the recognition
of a nonclassical nuclear localization
signal by importin beta Mol.Cell, 10, 2002
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8DYO
| Cryo-EM structure of Importin-4 bound to RanGTP | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | Authors: | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | Deposit date: | 2022-08-04 | Release date: | 2022-09-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
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8SGH
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6TVO
| Human CRM1-RanGTP in complex with Leptomycin B | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Shaikhqasem, A, Ficner, R. | Deposit date: | 2020-01-10 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Characterization of Inhibition Reveals Distinctive Properties for Human andSaccharomyces cerevisiaeCRM1. J.Med.Chem., 63, 2020
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7VPW
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3LWW
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4OO6
| Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) | Descriptor: | RNA-binding protein 39, Transportin-1 | Authors: | Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals) | Deposit date: | 2014-01-30 | Release date: | 2014-02-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) to be published
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