6TVO
Human CRM1-RanGTP in complex with Leptomycin B
Summary for 6TVO
| Entry DOI | 10.2210/pdb6tvo/pdb |
| Descriptor | GTP-binding nuclear protein Ran, Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | crm1, inhibitor, complex, exportin 1, nuclear protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 143857.01 |
| Authors | Shaikhqasem, A.,Ficner, R. (deposition date: 2020-01-10, release date: 2020-07-08, Last modification date: 2024-01-24) |
| Primary citation | Shaikhqasem, A.,Dickmanns, A.,Neumann, P.,Ficner, R. Characterization of Inhibition Reveals Distinctive Properties for Human andSaccharomyces cerevisiaeCRM1. J.Med.Chem., 63:7545-7558, 2020 Cited by PubMed: 32585100DOI: 10.1021/acs.jmedchem.0c00143 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.201 Å) |
Structure validation
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