6TVO
Human CRM1-RanGTP in complex with Leptomycin B
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | GTP-binding nuclear protein Ran | polymer | 182 | 20782.2 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
2 | A | Exportin-1 | polymer | 1060 | 121966.5 | 1 | UniProt (O14980) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Homo sapiens (Human) | Exp1,Chromosome region maintenance 1 protein homolog |
3 | B | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | A | Leptomycin B, bound form | non-polymer | 560.8 | 1 | Chemie (LMB) |
Sequence modifications
B: 1 - 180 (UniProt: P62826)
A: 1 - 1036 (UniProt: O14980)
PDB | External Database | Details |
---|---|---|
Met -1 | - | initiating methionine |
Gly 0 | - | expression tag |
Leu 69 | Gln 69 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
Ala -12 | - | expression tag |
Ser -11 | - | expression tag |
Met -10 | - | expression tag |
Thr -9 | - | expression tag |
Gly -8 | - | expression tag |
Gly -7 | - | expression tag |
Gln -6 | - | expression tag |
Gln -5 | - | expression tag |
Met -4 | - | expression tag |
Gly -3 | - | expression tag |
Arg -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 430 | Val 430 | engineered mutation |
Ala 431 | Leu 431 | engineered mutation |
Ala 432 | Val 432 | engineered mutation |
Arg 1037 | - | expression tag |
Ser 1038 | - | expression tag |
Arg 1039 | - | expression tag |
Ser 1040 | - | expression tag |
His 1041 | - | expression tag |
His 1042 | - | expression tag |
His 1043 | - | expression tag |
His 1044 | - | expression tag |
His 1045 | - | expression tag |
His 1046 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 142748.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1108.2 | |
All* | Total formula weight | 143857.0 |