6TVO

Human CRM1-RanGTP in complex with Leptomycin B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	GTP-binding nuclear protein Ran	polymer	182	20782.2	1	UniProt (P62826) Pfam (PF00071)	Homo sapiens (Human)	Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein
2	B (A)	Exportin-1	polymer	1060	121966.5	1	UniProt (O14980) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767)	Homo sapiens (Human)	Exp1,Chromosome region maintenance 1 protein homolog
3	C (B)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
4	D (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	E (A)	Leptomycin B, bound form	non-polymer		560.8	1	Chemie (LMB)

Sequence modifications

B: 1 - 180 (UniProt: P62826)

PDB	External Database	Details
Met -1	-	initiating methionine
Gly 0	-	expression tag
Leu 69	Gln 69	engineered mutation

A: 1 - 1036 (UniProt: O14980)

PDB	External Database	Details
Met -13	-	initiating methionine
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 430	Val 430	engineered mutation
Ala 431	Leu 431	engineered mutation
Ala 432	Val 432	engineered mutation
Arg 1037	-	expression tag
Ser 1038	-	expression tag
Arg 1039	-	expression tag
Ser 1040	-	expression tag
His 1041	-	expression tag
His 1042	-	expression tag
His 1043	-	expression tag
His 1044	-	expression tag
His 1045	-	expression tag
His 1046	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	142748.8
Non-Polymers*	Number of molecules	3
	Total formula weight	1108.2
All*	Total formula weight	143857.0

*Water molecules are not included.