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6OSM	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103 Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
8FPT	STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE Descriptor: Alpha-synuclein Authors: Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. Deposit date: 2023-01-05 Release date: 2023-02-22 Method: SOLID-STATE NMR Cite: Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Biorxiv, 2023
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6OSL	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122 Descriptor: Alpha-synuclein Authors: Ni, X, McGlinchey, R.P, Jiang, J, Lee, J.C. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
8GF7	Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein Authors: Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M. Deposit date: 2023-03-07 Release date: 2023-11-08 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology. Nat.Chem.Biol., 2024
6PES	Cryo-EM structure of alpha-synuclein H50Q Wide Fibril Descriptor: Alpha-synuclein Authors: Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
8H04	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8H05	Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8H03	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a preclinical Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
6PEO	Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril Descriptor: Alpha-synuclein Authors: Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
7NCA	Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2021-04-14 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCJ	Type 2AB alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2021-04-14 Method: ELECTRON MICROSCOPY (4.23 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCG	Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2021-04-14 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCI	Type 2B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2021-04-14 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCH	Type 1B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2021-04-14 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCK	Type 3 alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 5 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2021-04-14 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
8HZB	Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-08 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1) To Be Published
8HZC	Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-08 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2) To Be Published
8HZS	Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-09 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) To Be Published
8OQI	Cryo-EM structure of the wild-type alpha-synuclein fibril. Descriptor: Alpha-synuclein Authors: Pesch, V, Reithofer, S, Ma, L, Flores-Fernandez, J.M, Oezduezenciler, P, Busch, Y, Lien, Y, Rudtke, O, Frieg, B, Schroeder, G.F, Wille, H, Tamgueney, G. Deposit date: 2023-04-12 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease. Brain, 2024
8RQM	Alpha-synuclein amyloid fibrils Descriptor: Alpha-synuclein Authors: Saibil, H.R, Monistrol, J. Deposit date: 2024-01-18 Release date: 2024-02-28 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly Biorxiv, 2024
8RRR	Alpha-synuclein amyloid fibril Descriptor: Alpha-synuclein Authors: Saibil, H.R, Monistrol, J. Deposit date: 2024-01-23 Release date: 2024-02-28 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly Biorxiv, 2024
8RI9	Late alpha-Synuclein fibril structure from liquid-liquid phase separations. Descriptor: Alpha-synuclein Authors: De Simone, A, Barritt, J.D, Chen, S, Cascella, R, Cecchi, C, Bigi, A, Jarvis, J.A, Chiti, F, Dobson, C.M, Fusco, G. Deposit date: 2023-12-18 Release date: 2024-03-06 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates. J.Am.Chem.Soc., 2024
7UAK	Structure of recombinantly assembled A53E alpha-synuclein fibrils Descriptor: Alpha-synuclein Authors: Zhou, K, Zhou, H. Deposit date: 2022-03-13 Release date: 2023-03-29 Last modified: 2023-04-12 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Cryo-EM structure of amyloid fibril formed by alpha-synuclein hereditary A53E mutation reveals a distinct protofilament interface. J.Biol.Chem., 299, 2023
7V48	Type 1D alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2021-08-12 Release date: 2022-08-17 Last modified: 2023-01-25 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023

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