PDB: 44 resultsInfo pagesStatus searchChemie searchBIRD

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4YSI	Structure of USP7 with a novel viral protein Descriptor: GLYCEROL, SER-PRO-GLY-GLU-GLY-PRO-SER-GLY, Ubiquitin carboxyl-terminal hydrolase 7 Authors: Chavoshi, S, Saridakis, V. Deposit date: 2015-03-17 Release date: 2016-02-03 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.02 Å) Cite: Structure of USP7 with a novel viral protein J.Biol.Chem., 2016
6F8G	Co-crystal structure of SPOP MATH domain and hamster Pdx1 fragment Descriptor: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein Authors: Ostertag, M.S, Popowicz, G.M, Sattler, M. Deposit date: 2017-12-13 Release date: 2018-11-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.03 Å) Cite: The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation. Structure, 27, 2019
6F8F	Co-crystal structure of SPOP MATH domain and human Pdx1 fragment Descriptor: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein Authors: Ostertag, M.S, Popowicz, G.M, Sattler, M. Deposit date: 2017-12-13 Release date: 2018-11-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation. Structure, 27, 2019
6I41	Co-crystal structure of human SPOP MATH domain (wild-type) and human BRD3 fragment Descriptor: Bromodomain-containing protein 3, Speckle-type POZ protein Authors: Ostertag, M.S, Popowicz, G.M, Sattler, M. Deposit date: 2018-11-08 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. J.Mol.Biol., 431, 2019
6I5P	Co-crystal structure of human SPOP MATH domain (E47K) and human BRD3 fragment Descriptor: Bromodomain-containing protein 3, Speckle-type POZ protein Authors: Ostertag, M.S, Popowicz, G.M, Sattler, M. Deposit date: 2018-11-14 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. J.Mol.Biol., 431, 2019
6I68	Co-crystal structure of human SPOP MATH domain (M117V) and human BRD3 fragment Descriptor: Bromodomain-containing protein 3, Speckle-type POZ protein Authors: Ostertag, M.S, Popowicz, G.M, Sattler, M. Deposit date: 2018-11-15 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. J.Mol.Biol., 431, 2019
6I7A	Co-crystal structure of human SPOP MATH domain (D140N) and human BRD3 fragment Descriptor: Bromodomain-containing protein 3, Speckle-type POZ protein Authors: Ostertag, M.S, Popowicz, G.M, Sattler, M. Deposit date: 2018-11-16 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. J.Mol.Biol., 431, 2019
7D3D	Crystal structure of SPOP bound with a peptide Descriptor: GLU-VAL-SER-ILE-ILE-GLN-GLY-ALA-ASP-SER-THR-THR, GLYCEROL, Speckle-type POZ protein Authors: Yang, C.-G, Gan, J.H. Deposit date: 2020-09-18 Release date: 2020-11-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A peptide binder of E3 ligase adaptor SPOP disrupts oncogenic SPOP-protein interactions in kidney cancer cells. Chin.J.Chem., 39, 2021
7KLZ	Structure of SPOP MATH domain in complex with a Geminin peptide Descriptor: Geminin peptide, PHOSPHATE ION, Speckle-type POZ protein Authors: Cui, G, Botuyan, M.V, Mer, G. Deposit date: 2020-11-01 Release date: 2021-08-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.4 Å) Cite: SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Commun, 12, 2021
7KPI	Crystal structure of the SPOP MATH domain Descriptor: Speckle-type POZ protein Authors: Usher, E.T, Boal, A.K. Deposit date: 2020-11-11 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity. J.Biol.Chem., 296, 2021
7KPK	Crystal structure of the SPOP MATH domain in complex with a fragment of Pdx1 Descriptor: Pdx1 peptide, Speckle-type POZ protein Authors: Usher, E.T, Boal, A.K. Deposit date: 2020-11-11 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity. J.Biol.Chem., 296, 2021
7LIP	X-ray structure of SPOP MATH domain (D140G) Descriptor: SULFATE ION, Speckle-type POZ protein Authors: Botuyan, M.V, Cui, G, Mer, G. Deposit date: 2021-01-27 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.48 Å) Cite: ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Sci Adv, 7, 2021
7LIN	X-ray structure of SPOP MATH domain (D140G) in complex with a 53BP1 peptide Descriptor: SULFATE ION, Speckle-type POZ protein, TP53-binding protein 1 peptide Authors: Botuyan, M.V, Cui, G, Mer, G. Deposit date: 2021-01-27 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.44 Å) Cite: ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Sci Adv, 7, 2021
7LIO	X-ray structure of SPOP MATH domain (S119D) in complex with a 53BP1 peptide Descriptor: Speckle-type POZ protein, TP53-binding protein 1 peptide Authors: Botuyan, M.V, Cui, G, Mer, G. Deposit date: 2021-01-27 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.01 Å) Cite: ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Sci Adv, 7, 2021
7LIQ	X-ray structure of SPOP MATH domain (S119A) Descriptor: Speckle-type POZ protein Authors: Botuyan, M.V, Cui, G, Mer, G. Deposit date: 2021-01-27 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.98 Å) Cite: ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Sci Adv, 7, 2021
8DWT	SPOP W22R Form 2 Descriptor: Speckle-type POZ protein Authors: Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. Deposit date: 2022-08-02 Release date: 2023-01-18 Last modified: 2023-03-22 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
8DWU	SPOP W22R Form 1 Descriptor: Speckle-type POZ protein Authors: Cuneo, M.J, Mittag, T, O'Flynn, B. Deposit date: 2022-08-02 Release date: 2023-01-18 Last modified: 2023-03-22 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
8DWS	Full-length E47K SPOP Descriptor: Speckle-type POZ protein Authors: Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. Deposit date: 2022-08-02 Release date: 2023-01-18 Last modified: 2023-03-22 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023
8DWV	Full-length wild type SPOP Descriptor: Speckle-type POZ protein Authors: Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. Deposit date: 2022-08-02 Release date: 2023-01-18 Last modified: 2023-03-22 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation. Mol.Cell, 83, 2023

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