7KPK

Crystal structure of the SPOP MATH domain in complex with a fragment of Pdx1

Summary for 7KPK

• Entry DOI: 10.2210/pdb7kpk/pdb
• Descriptor: Speckle-type POZ protein, Pdx1 peptide (3 entities in total)
• Functional Keywords: ubiquitin, ligase, adaptor, protein, diabetes, transcription factor, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 18416.12

Authors

Usher, E.T.,Boal, A.K. (deposition date: 2020-11-11, release date: 2021-04-28, Last modification date: 2023-10-18)

• Primary citation: Usher, E.T.,Sabri, N.,Rohac, R.,Boal, A.K.,Mittag, T.,Showalter, S.A.; Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity.; J.Biol.Chem., 296:100693-100693, 2021; PubMed: 33894201; DOI: 10.1016/j.jbc.2021.100693

Experimental method

X-RAY DIFFRACTION (1.71 Å)