7D3D

Crystal structure of SPOP bound with a peptide

Summary for 7D3D

• Entry DOI: 10.2210/pdb7d3d/pdb
• Descriptor: Speckle-type POZ protein, GLU-VAL-SER-ILE-ILE-GLN-GLY-ALA-ASP-SER-THR-THR, GLYCEROL, ... (4 entities in total)
• Functional Keywords: ccrcc, e3 ligase adaptor spop, ubiquitination, sbc motif(f-ps-s/t-s/t;f is nonpolar, p is polar), protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 34815.87

Authors

Yang, C.-G.,Gan, J.H. (deposition date: 2020-09-18, release date: 2020-11-18, Last modification date: 2023-11-29)

• Primary citation: Wang, Z.,Zhang, H.,Chen, B.,Ouyang, T.,Zheng, T.,Zhou, R.,Dong, Z.,Huang, Y.,Zhang, T.,Jiang, H.,Gan, J.,Luo, C.,Yang, C.-G.; A peptide binder of E3 ligase adaptor SPOP disrupts oncogenic SPOP-protein interactions in kidney cancer cells.; Chin.J.Chem., 39:271-280, 2021; DOI: 10.1002/cjoc.202000462

Experimental method

X-RAY DIFFRACTION (1.45 Å)