6I68

Co-crystal structure of human SPOP MATH domain (M117V) and human BRD3 fragment

Summary for 6I68

• Entry DOI: 10.2210/pdb6i68/pdb
• Related: 6I41 6I5P
• Descriptor: Speckle-type POZ protein, Bromodomain-containing protein 3 (3 entities in total)
• Functional Keywords: ligase nuclear cancer ubiquitination, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 70080.27

Authors

Ostertag, M.S.,Popowicz, G.M.,Sattler, M. (deposition date: 2018-11-15, release date: 2019-05-08, Last modification date: 2024-01-24)

• Primary citation: Ostertag, M.S.,Hutwelker, W.,Plettenburg, O.,Sattler, M.,Popowicz, G.M.; Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.; J.Mol.Biol., 431:2213-2221, 2019; PubMed: 31026449; DOI: 10.1016/j.jmb.2019.04.017

Experimental method

X-RAY DIFFRACTION (1.85 Å)