8C07
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5TJ8
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5HPS
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5TJ7
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5TJQ
| Structure of WWP2 2,3-linker-HECT | Descriptor: | NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Chen, Z, Gabelli, S.B. | Deposit date: | 2016-10-04 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A Tunable Brake for HECT Ubiquitin Ligases. Mol. Cell, 66, 2017
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5HPK
| System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1 | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1 | Authors: | Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A. | Deposit date: | 2016-01-20 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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5HPT
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5HPL
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3JW0
| E2~Ubiquitin-HECT | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | Authors: | Kamadurai, H.B, Schulman, B.A. | Deposit date: | 2009-09-17 | Release date: | 2010-01-12 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
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3JVZ
| E2~Ubiquitin-HECT | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | Authors: | Souphron, J, Kamadurai, H.B, Schulman, B.A. | Deposit date: | 2009-09-17 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
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7MWD
| HUWE1 in map with focus on HECT | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2021-05-16 | Release date: | 2021-07-28 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
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7MWF
| HUWE1 in map with focus on interface | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2021-05-16 | Release date: | 2021-07-28 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
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7MWE
| HUWE1 in map with focus on WWE | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2021-05-16 | Release date: | 2021-07-28 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
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7MOP
| Cryo-EM structure of human HUWE1 in complex with DDIT4 | Descriptor: | DNA damage-inducible transcript 4 protein, E3 ubiquitin-protein ligase HUWE1 | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2021-05-03 | Release date: | 2021-07-28 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
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6J1Z
| WWP2 semi-open conformation | Descriptor: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Liu, Z.H. | Deposit date: | 2018-12-30 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10, 2019
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6J1X
| WWP1 close conformation | Descriptor: | GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1 | Authors: | Liu, Z.H. | Deposit date: | 2018-12-30 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10, 2019
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6J1Y
| Semi-open conformation E3 ligase | Descriptor: | GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1 | Authors: | Liu, Z.H. | Deposit date: | 2018-12-30 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10, 2019
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8Q0N
| HACE1 in complex with RAC1 Q61L | Descriptor: | E3 ubiquitin-protein ligase HACE1, GUANOSINE-5'-TRIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ... | Authors: | Wolter, M, Duering, J, Dienemann, C, Lorenz, S. | Deposit date: | 2023-07-28 | Release date: | 2024-01-10 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1. Nat.Struct.Mol.Biol., 31, 2024
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8R1G
| Dimeric ternary structure of E6AP-E6-p53 | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
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8R1F
| Monomeric E6AP-E6-p53 ternary complex | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
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8GCR
| HPV16 E6-E6AP-p53 complex | Descriptor: | Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. | Deposit date: | 2023-03-02 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
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