PDB: 141 件ウェブページステータス検索Chemie searchBIRD

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6PCV	Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 著者 Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. 登録日 2019-06-18 公開日 2019-10-23 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold. Sci Adv, 5, 2019
1NTY	Crystal structure of the first DH/PH domain of Trio to 1.7 A 分子名称: Triple functional domain protein 著者 Skowronek, K.R, Zheng, Y, Nassar, N. 登録日 2003-01-30 公開日 2004-06-29 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J.Biol.Chem., 279, 2004
6D8Z	Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio 分子名称: Triple functional domain protein 著者 Bandekar, S, Tesmer, J.J. 登録日 2018-04-27 公開日 2019-02-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Sci Signal, 12, 2019
6NF1	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity 分子名称: (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proto-oncogene vav, ... 著者 Knapp, M.S, Elling, R.A, Ornelas, E. 登録日 2018-12-18 公開日 2019-12-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
6NEW	Apo structure of the activated truncation of Vav1 分子名称: Proto-oncogene vav, ZINC ION 著者 Knapp, M.S, Elling, R.A, Ornelas, E. 登録日 2018-12-18 公開日 2019-12-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
2Z0Q	Crystal structure of DH-PH domain of RhoGEF3(Xpln) 分子名称: Rho guanine nucleotide exchange factor 3, SULFATE ION 著者 Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-05-07 公開日 2008-05-13 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F, 68, 2012
8BNT	The DH domain of ARHGEF2 bound to RhoA 分子名称: DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ... 著者 Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E. 登録日 2022-11-25 公開日 2022-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The DH domain of ARHGEF2 bound to RhoA To Be Published
2RGN	Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... 著者 Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. 登録日 2007-10-04 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
7RX9	Structure of autoinhibited P-Rex1 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION 著者 Ellisdon, A.M, Chang, Y. 登録日 2021-08-22 公開日 2022-08-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
6L30	Crystal structure of the epithelial cell transforming 2 (ECT2) 分子名称: Protein ECT2 著者 Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. 登録日 2019-10-07 公開日 2020-01-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
4D0N	AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA 分子名称: 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. 登録日 2014-04-29 公開日 2014-05-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
4MT7	Crystal structure of collybistin I 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
7SJ4	Human Trio residues 1284-1959 in complex with Rac1 分子名称: Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein 著者 Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. 登録日 2021-10-15 公開日 2022-07-06 最終更新日 2022-08-24 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J.Biol.Chem., 298, 2022
5FI0	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 分子名称: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.282 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
2VRW	Critical structural role for the PH and C1 domains of the Vav1 exchange factor 分子名称: PROTO-ONCOGENE VAV, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, ZINC ION 著者 Rapley, J, Tybulewicz, V, Rittinger, K. 登録日 2008-04-16 公開日 2008-06-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor. Embo Rep., 9, 2008
1RJ2	Crystal structure of the DH/PH fragment of Dbs without bound GTPase 分子名称: Guanine nucleotide exchange factor DBS [Fragment] 著者 Worthylake, D.K, Rossman, K.L, Sondek, J. 登録日 2003-11-18 公開日 2004-06-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the DH/PH fragment of Dbs without bound GTPase. Structure, 12, 2004
2NZ8	N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 分子名称: ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein 著者 Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. 登録日 2006-11-22 公開日 2007-04-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation J.Mol.Biol., 368, 2007
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
3JV3	Structure of SH3E-DH unit of murine intersectin-1L 分子名称: Intersectin-1 著者 Ahmad, K.F. 登録日 2009-09-15 公開日 2010-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. Plos One, 5, 2010
2DX1	Crystal structure of RhoGEF protein Asef 分子名称: Rho guanine nucleotide exchange factor 4 著者 Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-22 公開日 2007-01-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism J.Biol.Chem., 282, 2007
4MT6	Crystal structure of closed inactive collybistin 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (5.501 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
6NFA	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity 分子名称: (2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol, Proto-oncogene vav, ZINC ION 著者 Knapp, M.S, Elling, R.A, Ornelas, E. 登録日 2018-12-19 公開日 2019-12-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
3BJI	Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 分子名称: Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION 著者 Chrencik, J.E, Brooun, A, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) 登録日 2007-12-04 公開日 2008-07-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J.Mol.Biol., 380, 2008
2DFK	Crystal structure of the CDC42-Collybistin II complex 分子名称: GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ... 著者 Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H. 登録日 2006-03-02 公開日 2006-05-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor. J.Mol.Biol., 359, 2006
7CSP	Structure of Ephexin4 IDPSH 分子名称: Rho guanine nucleotide exchange factor 16 著者 Zhang, M, Lin, L, Wang, C, Zhu, J. 登録日 2020-08-15 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021

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