6NF1

Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity

Summary for 6NF1

• Entry DOI: 10.2210/pdb6nf1/pdb
• Related: 6NEW
• Descriptor: Proto-oncogene vav, (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: gef, rac, vav1, inhibitor, metal binding protein-inhibitor complex, metal binding protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 68166.42

Authors

Knapp, M.S.,Elling, R.A.,Ornelas, E. (deposition date: 2018-12-18, release date: 2019-12-25, Last modification date: 2023-10-11)

• Primary citation: Gerspacher, M.,Skaanderup, P.R.; Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)