6NF1
Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene vav | polymer | 578 | 67382.8 | 1 | UniProt (P15498) Pfam (PF00307) Pfam (PF00621) Pfam (PF00169) Pfam (PF00130) In PDB | Homo sapiens (Human) | |
| 2 | A | (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol | non-polymer | 457.6 | 1 | Chemie (9JY) | |||
| 3 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 2 - 575 (UniProt: P15498)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 67382.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 783.6 | |
| All* | Total formula weight | 68166.4 |
