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2W6O	Crystal structure of Biotin carboxylase from E. coli in complex with 4-Amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment Descriptor: 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W70	Crystal structure of Biotin carboxylase from E. coli in complex with the amino-thiazole-pyrimidine fragment Descriptor: 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-19 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6Q	Crystal structure of Biotin carboxylase from E. coli in complex with the triazine-2,4-diamine fragment Descriptor: 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W71	Crystal structure of Biotin carboxylase from E. coli in complex with the imidazole-pyrimidine inhibitor Descriptor: 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-19 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6P	Crystal structure of Biotin carboxylase from E. coli in complex with 5-Methyl-6-phenyl-quinazoline-2,4-diamine Descriptor: 5-methyl-6-phenylquinazoline-2,4-diamine, ACETYL-COA CARBOXYLASE Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6Z	Crystal structure of Biotin carboxylase from E. coli in complex with the 3-(3-Methyl-but-2-enyl)-3H-purin-6-ylamine fragment Descriptor: 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-19 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6M	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series Descriptor: (2-AMINO-1,3-OXAZOL-5-YL)-(3-BROMOPHENYL)METHANONE, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
3HBL	Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Tong, L, Yu, L.P.C. Deposit date: 2009-05-04 Release date: 2009-06-30 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (2.71 Å) Cite: A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3HB9	Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Tong, L, Yu, L.P.C. Deposit date: 2009-05-04 Release date: 2009-06-30 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3HO8	Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ... Authors: Tong, L, Yu, L.P.C. Deposit date: 2009-06-01 Release date: 2009-06-30 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3JZF	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series Descriptor: 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, Biotin carboxylase, CARBONATE ION Authors: Orth, P. Deposit date: 2009-09-23 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3JZI	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series Descriptor: 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide, Biotin carboxylase Authors: Cheng, C, Shipps, G.W, Yang, Z, Sun, B, Kawahata, N, Soucy, K, Soriano, A, Orth, P, Xiao, L, Mann, P, Black, T. Deposit date: 2009-09-23 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3JRW	Phosphorylated BC domain of ACC2 Descriptor: Acetyl-CoA carboxylase 2 Authors: Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. Deposit date: 2009-09-09 Release date: 2010-01-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK Biochem.Biophys.Res.Commun., 391, 2010
3JRX	Crystal structure of the BC domain of ACC2 in complex with soraphen A Descriptor: Acetyl-CoA carboxylase 2, SORAPHEN A Authors: Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. Deposit date: 2009-09-09 Release date: 2010-01-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem.Biophys.Res.Commun., 391, 2010
3N6R	CRYSTAL STRUCTURE OF the holoenzyme of PROPIONYL-COA CARBOXYLASE (PCC) Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-CoA carboxylase, alpha subunit, ... Authors: Huang, C.S, Sadre-Bazzaz, K, Tong, L. Deposit date: 2010-05-26 Release date: 2010-08-25 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase. Nature, 466, 2010
3OUZ	Crystal Structure of Biotin Carboxylase-ADP complex from Campylobacter jejuni Descriptor: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, D-MALATE, ... Authors: Maltseva, N, Kim, Y, Makowska-Grzyska, M, Mulligan, R, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2010-09-15 Release date: 2010-10-13 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (1.902 Å) Cite: Crystal Structure of Biotin Carboxylase-ADP complex from Campylobacter jejuni TO BE PUBLISHED
3OUU	Crystal Structure of Biotin Carboxylase-beta-gamma-ATP Complex from Campylobacter jejuni Descriptor: Biotin carboxylase, CACODYLATE ION, CALCIUM ION, ... Authors: Maltseva, N, Kim, Y, Makowska-Grzyska, M, Mulligan, R, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2010-09-15 Release date: 2010-10-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.252 Å) Cite: Crystal Structure of Biotin Carboxylase-beta-gamma-ATP Complex from Campylobacter jejuni TO BE PUBLISHED
3RUP	Crystal structure of E.coli biotin carboxylase in complex with two ADP and two Ca ions Descriptor: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, CALCIUM ION, ... Authors: Chou, C.Y, Tong, L. Deposit date: 2011-05-05 Release date: 2011-05-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization. J.Biol.Chem., 286, 2011
3RV4	Crystal structure of E.coli biotin carboxylase R16E mutant in complex with Mg-ADP and bicarbonate Descriptor: ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, Biotin carboxylase, ... Authors: Chou, C.Y, Tong, L. Deposit date: 2011-05-05 Release date: 2011-05-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization. J.Biol.Chem., 286, 2011
3RV3	Crystal structure of E.coli biotin carboxylase in complex with two ADP and one Mg ion Descriptor: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, MAGNESIUM ION Authors: Chou, C.Y, Tong, L. Deposit date: 2011-05-05 Release date: 2011-05-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization. J.Biol.Chem., 286, 2011
2YL2	Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain Descriptor: ACETYL-COA CARBOXYLASE 1 Authors: Muniz, J.R.C, Froese, D.S, Krysztofinska, E, Vollmar, M, Beltrami, A, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Yue, W.W, Oppermann, U. Deposit date: 2011-05-31 Release date: 2011-06-15 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain To be Published
3TW7	Structure of Rhizobium etli pyruvate carboxylase T882A crystallized without acetyl coenzyme-A Descriptor: CHLORIDE ION, MAGNESIUM ION, Pyruvate carboxylase protein, ... Authors: St Maurice, M, Kumar, S, Lietzan, A.D. Deposit date: 2011-09-21 Release date: 2011-10-12 Last modified: 2011-12-28 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli. Biochemistry, 50, 2011
3TW6	Structure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: St Maurice, M, Kumar, S, Lietzan, A.D. Deposit date: 2011-09-21 Release date: 2011-10-19 Last modified: 2011-12-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli. Biochemistry, 50, 2011
3U9T	Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme Descriptor: Methylcrotonyl-CoA carboxylase, alpha-subunit, beta-subunit Authors: Huang, C.S, Tong, L. Deposit date: 2011-10-19 Release date: 2011-12-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature, 481, 2012
3U9S	Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, CoA complex Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Methylcrotonyl-CoA carboxylase, ... Authors: Huang, C.S, Tong, L. Deposit date: 2011-10-19 Release date: 2011-12-14 Last modified: 2013-01-23 Method: X-RAY DIFFRACTION (3.5 Å) Cite: An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature, 481, 2012

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