2W6Q
Crystal structure of Biotin carboxylase from E. coli in complex with the triazine-2,4-diamine fragment
Summary for 2W6Q
Entry DOI | 10.2210/pdb2w6q/pdb |
Related | 1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V59 2V5A 2VR1 2W6M 2W6N 2W6O 2W6P 2W6Z 2W70 2W71 2W7C |
Descriptor | BIOTIN CARBOXYLASE, 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | ligase, atp-binding, fatty acid biosynthesis, nucleotide-binding, lipid synthesis, atp-grasp domain, fragment screening |
Biological source | ESCHERICHIA COLI |
Total number of polymer chains | 2 |
Total formula weight | 99338.72 |
Authors | Mochalkin, I.,Miller, J.R. (deposition date: 2008-12-18, release date: 2009-05-19, Last modification date: 2023-12-13) |
Primary citation | Mochalkin, I.,Miller, J.R.,Narasimhan, L.S.,Thanabal, V.,Erdman, P.,Cox, P.,Prasad, J.V.,Lightle, S.,Huband, M.,Stover, K. Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4:473-, 2009 Cited by PubMed: 19413326DOI: 10.1021/CB9000102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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