3JZF

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series

Summary for 3JZF

Entry DOI	10.2210/pdb3jzf/pdb
Related	3JZI
Descriptor	Biotin carboxylase, CARBONATE ION, 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, ... (4 entities in total)
Functional Keywords	biotin carboxylase, accc, acetyl coenzyme-a carboxylase, accase, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, nucleotide-binding
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	107471.04
Authors	Orth, P. (deposition date: 2009-09-23, release date: 2009-11-03, Last modification date: 2023-09-06)
Primary citation	Cheng, C.C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.A.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19:6507-6514, 2009 Cited by PubMed: 19875284 DOI: 10.1016/j.bmcl.2009.10.057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation