2W6Z

Crystal structure of Biotin carboxylase from E. coli in complex with the 3-(3-Methyl-but-2-enyl)-3H-purin-6-ylamine fragment

Summary for 2W6Z

• Entry DOI: 10.2210/pdb2w6z/pdb
• Related: 1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V59 2V5A 2VR1 2W6M 2W6N 2W6O 2W6P 2W6Q 2W70 2W71 2W7C
• Descriptor: BIOTIN CARBOXYLASE, 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: ligase, atp-binding, fatty acid biosynthesis, nucleotide-binding, lipid synthesis, atp-grasp domain, fragment screening
• Biological source: ESCHERICHIA COLI
• Total number of polymer chains: 2
• Total formula weight: 99047.46

Authors

Mochalkin, I.,Miller, J.R. (deposition date: 2008-12-19, release date: 2009-05-19, Last modification date: 2023-12-13)

• Primary citation: Mochalkin, I.,Miller, J.R.,Narasimhan, L.S.,Thanabal, V.,Erdman, P.,Cox, P.,Prasad, J.V.,Lightle, S.,Huband, M.,Stover, K.; Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.; Acs Chem.Biol., 4:473-, 2009; PubMed: 19413326; DOI: 10.1021/CB9000102

Experimental method

X-RAY DIFFRACTION (1.9 Å)