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2V59

CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 2

Summary for 2V59
Entry DOI10.2210/pdb2v59/pdb
Related1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V5A 2VR1
DescriptorBIOTIN CARBOXYLASE, 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE (3 entities in total)
Functional Keywordsfatty acid biosynthesis, biotin carboxylase, nucleotide-binding, atp-binding, antibacterial, lipid synthesis, fas, ligase, biotin, bacterial, inhibitor
Biological sourceESCHERICHIA COLI
Total number of polymer chains2
Total formula weight99367.94
Authors
Mochalkin, I.,Miller, J.R. (deposition date: 2008-10-02, release date: 2009-01-13, Last modification date: 2023-12-13)
Primary citationMiller, J.R.,Dunham, S.,Mochalkin, I.,Banotai, C.,Bowman, M.,Buist, S.,Dunkle, B.,Hanna, D.,Harwood, H.J.,Huband, M.D.,Karnovsky, A.,Kuhn, M.,Limberakis, C.,Liu, J.Y.,Mehrens, S.,Mueller, W.T.,Narasimhan, L.,Ogden, A.,Ohren, J.,Prasad, J.V.,Shelly, J.A.,Skerlos, L.,Sulavik, M.,Thomas, V.H.,Vanderroest, S.,Wang, L.,Wang, Z.,Whitton, A.,Zhu, T.,Stover, C.K.
A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore.
Proc.Natl.Acad.Sci.USA, 106:1737-, 2009
Cited by
PubMed: 19164768
DOI: 10.1073/PNAS.0811275106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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