PDB: 223 resultsInfo pagesStatus searchChemie searchBIRD

---

4AJB	3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with Isocitrate, magnesium(II) and thioNADP Descriptor: 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, MAGNESIUM ION, ... Authors: Goncalves, S, Miller, S.P, Carrondo, M.A, Dean, A.M, Matias, P.M. Deposit date: 2012-02-16 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase. Biochemistry, 51, 2012
4AJS	3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with isocitrate, magnesium(II), Adenosine 2',5'-biphosphate and ribosylnicotinamide-5'-phosphate Descriptor: ADENOSINE-2'-5'-DIPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ISOCITRATE DEHYDROGENASE [NADP], ... Authors: Goncalves, S, Miller, S.P, Carrondo, M.A, Dean, A.M, Matias, P.M. Deposit date: 2012-02-17 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase. Biochemistry, 51, 2012
4AJR	3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with alpha-ketoglutarate, magnesium(II) and NADPH - The product complex Descriptor: 2-OXOGLUTARIC ACID, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ISOCITRATE DEHYDROGENASE [NADP], ... Authors: Goncalves, S, Miller, S.P, Carrondo, M.A, Dean, A.M, Matias, P.M. Deposit date: 2012-02-17 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.687 Å) Cite: Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase. Biochemistry, 51, 2012
4Y1P	Crystal structure of 3-isopropylmalate dehydrogenase (Saci_0600) from Sulfolobus acidocaldarius complex with 3-isopropylmalate and Mg2+ Descriptor: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, MAGNESIUM ION, ... Authors: Takahashi, K, Tomita, T, Kuzuyama, T, Nishiyama, M. Deposit date: 2015-02-08 Release date: 2016-03-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Characterization of two beta-decarboxylating dehydrogenases from Sulfolobus acidocaldarius Extremophiles, 20, 2016
4F7I	Structure of Isopropylmalate dehydrogenase from Thermus thermophilus in complex with IPM, Mn and NADH Descriptor: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... Authors: Pallo, A, Graczer, E, Zavodszky, P, Weiss, M.S, Vas, M. Deposit date: 2012-05-16 Release date: 2012-06-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis. Febs J., 281, 2014
4HCX	Structure of ICDH-1 from M.tuberculosis complexed with NADPH & Mn2+ Descriptor: CHLORIDE ION, Isocitrate dehydrogenase [NADP], MANGANESE (II) ION, ... Authors: Hazra, S, Blanchard, J. Deposit date: 2012-10-01 Release date: 2013-02-27 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis. Biochemistry, 52, 2013
4AJ3	3D structure of E. coli Isocitrate Dehydrogenase in complex with Isocitrate, calcium(II) and NADP - The pseudo-Michaelis complex Descriptor: CALCIUM ION, ISOCITRIC ACID, NADP ISOCITRATE DEHYDROGENASE, ... Authors: Goncalves, S, Miller, S.P, Carrondo, M.A, Dean, A.M, Matias, P.M. Deposit date: 2012-02-15 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase. Biochemistry, 51, 2012
4XXV	Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD Descriptor: 3-isopropylmalate dehydrogenase, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-01-31 Release date: 2015-02-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD to be published
4AJA	3D structure of E. coli Isocitrate Dehydrogenase in complex with Isocitrate, calcium(II) and thioNADP Descriptor: 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION, ISOCITRIC ACID, ... Authors: Goncalves, S, Miller, S.P, Carrondo, M.A, Dean, A.M, Matias, P.M. Deposit date: 2012-02-16 Release date: 2012-10-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.799 Å) Cite: Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase. Biochemistry, 51, 2012
4XS3	Crystal structure of a metabolic reductase with (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one Descriptor: (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Zheng, B, Wu, F, Jiang, H, Kogiso, M, Yao, Y, Zhou, C, Li, X, Song, Y. Deposit date: 2015-01-21 Release date: 2016-07-27 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.291 Å) Cite: Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J.Med.Chem., 58, 2015
4XRX	Crystal structure of a metabolic reductase with (E)-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one Descriptor: 5-[(E)-(1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl]pyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Zheng, B, Wu, F, Jiang, H, Kogiso, M, Yao, Y, Zhou, C, Li, X, Song, Y. Deposit date: 2015-01-21 Release date: 2015-12-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J.Med.Chem., 58, 2015
4BNP	3D structure of E. coli Isocitrate Dehydrogenase K100M mutant in complex with isocitrate and magnesium(II) Descriptor: ISOCITRATE DEHYDROGENASE [NADP], ISOCITRIC ACID, MAGNESIUM ION, ... Authors: Miller, S.P, Goncalves, S, Matias, P.M, Dean, A.M. Deposit date: 2013-05-16 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Evolution of a Transition State: Role of Lys100 in the Active Site of Isocitrate Dehydrogenase. Chembiochem, 15, 2014
4I3L	Crystal structure of a metabolic reductase with 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one Descriptor: 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Zheng, B, Yao, Y, Liu, Z, Deng, L, Anglin, J.L, Jiang, H, Prasad, B.V.V, Song, Y. Deposit date: 2012-11-26 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.292 Å) Cite: Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett, 4, 2013
4ICD	REGULATION OF ISOCITRATE DEHYDROGENASE BY PHOSPHORYLATION INVOLVES NO LONG-RANGE CONFORMATIONAL CHANGE IN THE FREE ENZYME Descriptor: PHOSPHORYLATED ISOCITRATE DEHYDROGENASE Authors: Hurley, J.H, Dean, A.M, Thorsness, P.E, Koshlandjunior, D.E, Stroud, R.M. Deposit date: 1989-12-28 Release date: 1991-01-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. J.Biol.Chem., 265, 1990
4YB4	Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium ion (II) and NADH Descriptor: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Takahashi, K, Tomita, T, Kuzuyama, T, Nishiyama, M. Deposit date: 2015-02-18 Release date: 2016-03-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium(II) and NADH To Be Published
2AYQ	3-ISOPROPYLMALATE DEHYDROGENASE FROM THE MODERATE FACULTATIVE THERMOPHILE, BACILLUS COAGULANS Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE Authors: Tsuchiya, D, Takenaka, A. Deposit date: 1998-02-20 Release date: 1998-05-27 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of 3-isopropylmalate dehydrogenase from the moderate facultative thermophile, Bacillus coagulans: two strategies for thermostabilization of protein structures. J.Biochem.(Tokyo), 122, 1997
4I3K	Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one Descriptor: 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Zheng, B, Yao, Y, Liu, Z, Deng, L, Anglin, J.L, Jiang, H, Prasad, B.V.V, Song, Y. Deposit date: 2012-11-26 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.3056 Å) Cite: Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett, 4, 2013
4IWH	Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei Descriptor: 3-isopropylmalate dehydrogenase, MAGNESIUM ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-01-23 Release date: 2013-02-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei TO BE PUBLISHED
2D4V	Crystal structure of NAD dependent isocitrate dehydrogenase from Acidithiobacillus thiooxidans Descriptor: CITRATE ANION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, isocitrate dehydrogenase Authors: Imada, K, Tamura, T, Namba, K, Inagaki, K. Deposit date: 2005-10-24 Release date: 2006-11-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: hydride transfer and co-factor specificity Proteins, 70, 2008
2DHT	Crystal structure of isocitrate dehydrogenase from Sulfolobus tokodaii strain7 Descriptor: 409aa long hypothetical NADP-dependent isocitrate dehydrogenase Authors: Kondo, H, Murakami, M, Ihara, K, Suzuki, S, Kouyama, T. Deposit date: 2006-03-25 Release date: 2007-03-27 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of isocitrate dehydrogenase of Sulfolobus tokodaii strain7 To be Published
2E0C	crystal structure of isocitrate dehydrogenase from Sulfolobus tokodaii strain7 at 2.0 A resolution Descriptor: 409aa long hypothetical NADP-dependent isocitrate dehydrogenase Authors: Kouyama, T. Deposit date: 2006-10-06 Release date: 2007-10-30 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of the Putative Isocitrate Dehydrogenase fromSulfolobus tokodaiiStrain 7 in the Apo and NADP+-Bound Forms. Archaea, 2018, 2018
2E5M	Crystal structure of isocitrate dehydrogenase from Sulfolobus tokodaii strain 7 Descriptor: 409aa long hypothetical NADP-dependent isocitrate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Kouyama, T, Kondo, H. Deposit date: 2006-12-22 Release date: 2008-01-15 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures of the Putative Isocitrate Dehydrogenase fromSulfolobus tokodaiiStrain 7 in the Apo and NADP+-Bound Forms. Archaea, 2018, 2018
1SJS	ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING Descriptor: ISOCITRATE DEHYDROGENASE Authors: Finer-Moore, J, Stroud, R.M. Deposit date: 1997-07-08 Release date: 1997-12-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting. Biochemistry, 36, 1997
1TYO	Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix in complex with etheno-NADP Descriptor: ETHENO-NADP, isocitrate dehydrogenase Authors: Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N, Ladenstein, R. Deposit date: 2004-07-08 Release date: 2005-07-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability J.Mol.Biol., 345, 2005
5GRL	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), isocitrate and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ISOCITRIC ACID, Isocitrate dehydrogenase [NAD] subunit alpha, ... Authors: Ma, T, Ding, J. Deposit date: 2016-08-11 Release date: 2017-02-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 7, 2017

<123456789>