7L7B
| Clostridioides difficile RNAP with fidaxomicin | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. | 登録日 | 2020-12-28 | 公開日 | 2022-02-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
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7MKD
| Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | 登録日 | 2021-04-23 | 公開日 | 2021-09-29 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKE
| Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | 登録日 | 2021-04-23 | 公開日 | 2021-09-29 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKI
| Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | 登録日 | 2021-04-23 | 公開日 | 2021-09-29 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKJ
| Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | 登録日 | 2021-04-23 | 公開日 | 2021-09-29 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MLB
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7MLI
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7MLJ
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7N4E
| Escherichia coli sigma 70-dependent paused transcription elongation complex | 分子名称: | 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Molodtsov, V, Su, M, Ebright, R.H. | 登録日 | 2021-06-04 | 公開日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
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7P5X
| Mycobacterial RNAP with transcriptional activator PafBC | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | 登録日 | 2021-07-15 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
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7PP4
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7Q4U
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7Q59
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7RDQ
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7SZJ
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7SZK
| Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex | 分子名称: | (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Shin, Y, Murakami, K.S. | 登録日 | 2021-11-28 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
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7U22
| Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 | 分子名称: | (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Molodtsov, V, Ebright, R.H. | 登録日 | 2022-02-22 | 公開日 | 2022-10-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.87 Å) | 主引用文献 | Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61, 2022
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7UBM
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7UBN
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7VF9
| Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | He, D.W, You, L.L, Zhang, Y. | 登録日 | 2021-09-10 | 公開日 | 2022-07-27 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | 主引用文献 | Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
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7VPD
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7VPZ
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7VWY
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7VWZ
| Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Lin, W, Feng, Y, Shi, J. | 登録日 | 2021-11-12 | 公開日 | 2022-06-08 | 最終更新日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
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7W5W
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