7Q4U

Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB

This is a non-PDB format compatible entry.

Summary for 7Q4U

• Entry DOI: 10.2210/pdb7q4u/pdb
• Related: 7PP4
• EMDB information: 13817
• Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (7 entities in total)
• Functional Keywords: dna-dependent rna polymerase, alternative sigma, transcription
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 48
• Total formula weight: 3224883.04

Authors

Brodolin, K. (deposition date: 2021-11-02, release date: 2022-11-16, Last modification date: 2023-02-08)

• Primary citation: Morichaud, Z.,Trapani, S.,Vishwakarma, R.K.,Chaloin, L.,Lionne, C.,Lai-Kee-Him, J.,Bron, P.,Brodolin, K.; Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization; Nat Commun, 14:484-, 2023; DOI: 10.1038/s41467-023-36113-y

Experimental method

ELECTRON MICROSCOPY (4.39 Å)