7Q4U

Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006351	biological_process	DNA-templated transcription
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
AA	0000428	cellular_component	DNA-directed RNA polymerase complex
AA	0003677	molecular_function	DNA binding
AA	0003899	molecular_function	DNA-directed RNA polymerase activity
AA	0005737	cellular_component	cytoplasm
AA	0005829	cellular_component	cytosol
AA	0005886	cellular_component	plasma membrane
AA	0006351	biological_process	DNA-templated transcription
AA	0009274	cellular_component	peptidoglycan-based cell wall
AA	0016740	molecular_function	transferase activity
AA	0016779	molecular_function	nucleotidyltransferase activity
AA	0034062	molecular_function	5'-3' RNA polymerase activity
AA	0046983	molecular_function	protein dimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006351	biological_process	DNA-templated transcription
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
BA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
BA	0000428	cellular_component	DNA-directed RNA polymerase complex
BA	0003677	molecular_function	DNA binding
BA	0003899	molecular_function	DNA-directed RNA polymerase activity
BA	0005515	molecular_function	protein binding
BA	0005829	cellular_component	cytosol
BA	0005886	cellular_component	plasma membrane
BA	0006351	biological_process	DNA-templated transcription
BA	0006352	biological_process	DNA-templated transcription initiation
BA	0006354	biological_process	DNA-templated transcription elongation
BA	0009274	cellular_component	peptidoglycan-based cell wall
BA	0016740	molecular_function	transferase activity
BA	0016779	molecular_function	nucleotidyltransferase activity
BA	0032549	molecular_function	ribonucleoside binding
BA	0034062	molecular_function	5'-3' RNA polymerase activity
BA	0046677	biological_process	response to antibiotic
C	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006351	biological_process	DNA-templated transcription
C	0006352	biological_process	DNA-templated transcription initiation
C	0006354	biological_process	DNA-templated transcription elongation
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
C	0046677	biological_process	response to antibiotic
CA	0000287	molecular_function	magnesium ion binding
CA	0000428	cellular_component	DNA-directed RNA polymerase complex
CA	0003677	molecular_function	DNA binding
CA	0003899	molecular_function	DNA-directed RNA polymerase activity
CA	0005829	cellular_component	cytosol
CA	0005886	cellular_component	plasma membrane
CA	0006351	biological_process	DNA-templated transcription
CA	0008270	molecular_function	zinc ion binding
CA	0009274	cellular_component	peptidoglycan-based cell wall
CA	0016740	molecular_function	transferase activity
CA	0016779	molecular_function	nucleotidyltransferase activity
CA	0034062	molecular_function	5'-3' RNA polymerase activity
CA	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046872	molecular_function	metal ion binding
DA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
DA	0000428	cellular_component	DNA-directed RNA polymerase complex
DA	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
DA	0003677	molecular_function	DNA binding
DA	0003899	molecular_function	DNA-directed RNA polymerase activity
DA	0005829	cellular_component	cytosol
DA	0006351	biological_process	DNA-templated transcription
DA	0006352	biological_process	DNA-templated transcription initiation
DA	0009274	cellular_component	peptidoglycan-based cell wall
DA	0016740	molecular_function	transferase activity
DA	0016779	molecular_function	nucleotidyltransferase activity
DA	0034062	molecular_function	5'-3' RNA polymerase activity
E	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006352	biological_process	DNA-templated transcription initiation
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
EA	0000976	molecular_function	transcription cis-regulatory region binding
EA	0001666	biological_process	response to hypoxia
EA	0003677	molecular_function	DNA binding
EA	0003700	molecular_function	DNA-binding transcription factor activity
EA	0003899	molecular_function	DNA-directed RNA polymerase activity
EA	0005515	molecular_function	protein binding
EA	0005829	cellular_component	cytosol
EA	0005886	cellular_component	plasma membrane
EA	0006351	biological_process	DNA-templated transcription
EA	0006352	biological_process	DNA-templated transcription initiation
EA	0006355	biological_process	regulation of DNA-templated transcription
EA	0009408	biological_process	response to heat
EA	0009410	biological_process	response to xenobiotic stimulus
EA	0016987	molecular_function	sigma factor activity
EA	0043175	molecular_function	RNA polymerase core enzyme binding
EA	0045893	biological_process	positive regulation of DNA-templated transcription
EA	1903865	cellular_component	sigma factor antagonist complex
EA	2000142	biological_process	regulation of DNA-templated transcription initiation
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0001666	biological_process	response to hypoxia
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006351	biological_process	DNA-templated transcription
F	0006352	biological_process	DNA-templated transcription initiation
F	0006355	biological_process	regulation of DNA-templated transcription
F	0009408	biological_process	response to heat
F	0009410	biological_process	response to xenobiotic stimulus
F	0016987	molecular_function	sigma factor activity
F	0043175	molecular_function	RNA polymerase core enzyme binding
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	1903865	cellular_component	sigma factor antagonist complex
F	2000142	biological_process	regulation of DNA-templated transcription initiation
FA	0000428	cellular_component	DNA-directed RNA polymerase complex
FA	0003677	molecular_function	DNA binding
FA	0003899	molecular_function	DNA-directed RNA polymerase activity
FA	0005737	cellular_component	cytoplasm
FA	0005829	cellular_component	cytosol
FA	0005886	cellular_component	plasma membrane
FA	0006351	biological_process	DNA-templated transcription
FA	0009274	cellular_component	peptidoglycan-based cell wall
FA	0016740	molecular_function	transferase activity
FA	0016779	molecular_function	nucleotidyltransferase activity
FA	0034062	molecular_function	5'-3' RNA polymerase activity
FA	0046983	molecular_function	protein dimerization activity
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0003677	molecular_function	DNA binding
G	0003899	molecular_function	DNA-directed RNA polymerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006351	biological_process	DNA-templated transcription
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0016740	molecular_function	transferase activity
G	0016779	molecular_function	nucleotidyltransferase activity
G	0034062	molecular_function	5'-3' RNA polymerase activity
G	0046983	molecular_function	protein dimerization activity
GA	0000428	cellular_component	DNA-directed RNA polymerase complex
GA	0003677	molecular_function	DNA binding
GA	0003899	molecular_function	DNA-directed RNA polymerase activity
GA	0005737	cellular_component	cytoplasm
GA	0005829	cellular_component	cytosol
GA	0005886	cellular_component	plasma membrane
GA	0006351	biological_process	DNA-templated transcription
GA	0009274	cellular_component	peptidoglycan-based cell wall
GA	0016740	molecular_function	transferase activity
GA	0016779	molecular_function	nucleotidyltransferase activity
GA	0034062	molecular_function	5'-3' RNA polymerase activity
GA	0046983	molecular_function	protein dimerization activity
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006351	biological_process	DNA-templated transcription
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0034062	molecular_function	5'-3' RNA polymerase activity
H	0046983	molecular_function	protein dimerization activity
HA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
HA	0000428	cellular_component	DNA-directed RNA polymerase complex
HA	0003677	molecular_function	DNA binding
HA	0003899	molecular_function	DNA-directed RNA polymerase activity
HA	0005515	molecular_function	protein binding
HA	0005829	cellular_component	cytosol
HA	0005886	cellular_component	plasma membrane
HA	0006351	biological_process	DNA-templated transcription
HA	0006352	biological_process	DNA-templated transcription initiation
HA	0006354	biological_process	DNA-templated transcription elongation
HA	0009274	cellular_component	peptidoglycan-based cell wall
HA	0016740	molecular_function	transferase activity
HA	0016779	molecular_function	nucleotidyltransferase activity
HA	0032549	molecular_function	ribonucleoside binding
HA	0034062	molecular_function	5'-3' RNA polymerase activity
HA	0046677	biological_process	response to antibiotic
I	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0003677	molecular_function	DNA binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006351	biological_process	DNA-templated transcription
I	0006352	biological_process	DNA-templated transcription initiation
I	0006354	biological_process	DNA-templated transcription elongation
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0016740	molecular_function	transferase activity
I	0016779	molecular_function	nucleotidyltransferase activity
I	0032549	molecular_function	ribonucleoside binding
I	0034062	molecular_function	5'-3' RNA polymerase activity
I	0046677	biological_process	response to antibiotic
IA	0000287	molecular_function	magnesium ion binding
IA	0000428	cellular_component	DNA-directed RNA polymerase complex
IA	0003677	molecular_function	DNA binding
IA	0003899	molecular_function	DNA-directed RNA polymerase activity
IA	0005829	cellular_component	cytosol
IA	0005886	cellular_component	plasma membrane
IA	0006351	biological_process	DNA-templated transcription
IA	0008270	molecular_function	zinc ion binding
IA	0009274	cellular_component	peptidoglycan-based cell wall
IA	0016740	molecular_function	transferase activity
IA	0016779	molecular_function	nucleotidyltransferase activity
IA	0034062	molecular_function	5'-3' RNA polymerase activity
IA	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006351	biological_process	DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0009274	cellular_component	peptidoglycan-based cell wall
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0034062	molecular_function	5'-3' RNA polymerase activity
J	0046872	molecular_function	metal ion binding
JA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
JA	0000428	cellular_component	DNA-directed RNA polymerase complex
JA	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
JA	0003677	molecular_function	DNA binding
JA	0003899	molecular_function	DNA-directed RNA polymerase activity
JA	0005829	cellular_component	cytosol
JA	0006351	biological_process	DNA-templated transcription
JA	0006352	biological_process	DNA-templated transcription initiation
JA	0009274	cellular_component	peptidoglycan-based cell wall
JA	0016740	molecular_function	transferase activity
JA	0016779	molecular_function	nucleotidyltransferase activity
JA	0034062	molecular_function	5'-3' RNA polymerase activity
K	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005829	cellular_component	cytosol
K	0006351	biological_process	DNA-templated transcription
K	0006352	biological_process	DNA-templated transcription initiation
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0016740	molecular_function	transferase activity
K	0016779	molecular_function	nucleotidyltransferase activity
K	0034062	molecular_function	5'-3' RNA polymerase activity
KA	0000976	molecular_function	transcription cis-regulatory region binding
KA	0001666	biological_process	response to hypoxia
KA	0003677	molecular_function	DNA binding
KA	0003700	molecular_function	DNA-binding transcription factor activity
KA	0003899	molecular_function	DNA-directed RNA polymerase activity
KA	0005515	molecular_function	protein binding
KA	0005829	cellular_component	cytosol
KA	0005886	cellular_component	plasma membrane
KA	0006351	biological_process	DNA-templated transcription
KA	0006352	biological_process	DNA-templated transcription initiation
KA	0006355	biological_process	regulation of DNA-templated transcription
KA	0009408	biological_process	response to heat
KA	0009410	biological_process	response to xenobiotic stimulus
KA	0016987	molecular_function	sigma factor activity
KA	0043175	molecular_function	RNA polymerase core enzyme binding
KA	0045893	biological_process	positive regulation of DNA-templated transcription
KA	1903865	cellular_component	sigma factor antagonist complex
KA	2000142	biological_process	regulation of DNA-templated transcription initiation
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0001666	biological_process	response to hypoxia
L	0003677	molecular_function	DNA binding
L	0003700	molecular_function	DNA-binding transcription factor activity
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006351	biological_process	DNA-templated transcription
L	0006352	biological_process	DNA-templated transcription initiation
L	0006355	biological_process	regulation of DNA-templated transcription
L	0009408	biological_process	response to heat
L	0009410	biological_process	response to xenobiotic stimulus
L	0016987	molecular_function	sigma factor activity
L	0043175	molecular_function	RNA polymerase core enzyme binding
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	1903865	cellular_component	sigma factor antagonist complex
L	2000142	biological_process	regulation of DNA-templated transcription initiation
LA	0000428	cellular_component	DNA-directed RNA polymerase complex
LA	0003677	molecular_function	DNA binding
LA	0003899	molecular_function	DNA-directed RNA polymerase activity
LA	0005737	cellular_component	cytoplasm
LA	0005829	cellular_component	cytosol
LA	0005886	cellular_component	plasma membrane
LA	0006351	biological_process	DNA-templated transcription
LA	0009274	cellular_component	peptidoglycan-based cell wall
LA	0016740	molecular_function	transferase activity
LA	0016779	molecular_function	nucleotidyltransferase activity
LA	0034062	molecular_function	5'-3' RNA polymerase activity
LA	0046983	molecular_function	protein dimerization activity
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed RNA polymerase activity
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006351	biological_process	DNA-templated transcription
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034062	molecular_function	5'-3' RNA polymerase activity
M	0046983	molecular_function	protein dimerization activity
MA	0000428	cellular_component	DNA-directed RNA polymerase complex
MA	0003677	molecular_function	DNA binding
MA	0003899	molecular_function	DNA-directed RNA polymerase activity
MA	0005737	cellular_component	cytoplasm
MA	0005829	cellular_component	cytosol
MA	0005886	cellular_component	plasma membrane
MA	0006351	biological_process	DNA-templated transcription
MA	0009274	cellular_component	peptidoglycan-based cell wall
MA	0016740	molecular_function	transferase activity
MA	0016779	molecular_function	nucleotidyltransferase activity
MA	0034062	molecular_function	5'-3' RNA polymerase activity
MA	0046983	molecular_function	protein dimerization activity
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed RNA polymerase activity
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006351	biological_process	DNA-templated transcription
N	0009274	cellular_component	peptidoglycan-based cell wall
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0034062	molecular_function	5'-3' RNA polymerase activity
N	0046983	molecular_function	protein dimerization activity
NA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
NA	0000428	cellular_component	DNA-directed RNA polymerase complex
NA	0003677	molecular_function	DNA binding
NA	0003899	molecular_function	DNA-directed RNA polymerase activity
NA	0005515	molecular_function	protein binding
NA	0005829	cellular_component	cytosol
NA	0005886	cellular_component	plasma membrane
NA	0006351	biological_process	DNA-templated transcription
NA	0006352	biological_process	DNA-templated transcription initiation
NA	0006354	biological_process	DNA-templated transcription elongation
NA	0009274	cellular_component	peptidoglycan-based cell wall
NA	0016740	molecular_function	transferase activity
NA	0016779	molecular_function	nucleotidyltransferase activity
NA	0032549	molecular_function	ribonucleoside binding
NA	0034062	molecular_function	5'-3' RNA polymerase activity
NA	0046677	biological_process	response to antibiotic
O	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
O	0000428	cellular_component	DNA-directed RNA polymerase complex
O	0003677	molecular_function	DNA binding
O	0003899	molecular_function	DNA-directed RNA polymerase activity
O	0005515	molecular_function	protein binding
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006351	biological_process	DNA-templated transcription
O	0006352	biological_process	DNA-templated transcription initiation
O	0006354	biological_process	DNA-templated transcription elongation
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0016740	molecular_function	transferase activity
O	0016779	molecular_function	nucleotidyltransferase activity
O	0032549	molecular_function	ribonucleoside binding
O	0034062	molecular_function	5'-3' RNA polymerase activity
O	0046677	biological_process	response to antibiotic
OA	0000287	molecular_function	magnesium ion binding
OA	0000428	cellular_component	DNA-directed RNA polymerase complex
OA	0003677	molecular_function	DNA binding
OA	0003899	molecular_function	DNA-directed RNA polymerase activity
OA	0005829	cellular_component	cytosol
OA	0005886	cellular_component	plasma membrane
OA	0006351	biological_process	DNA-templated transcription
OA	0008270	molecular_function	zinc ion binding
OA	0009274	cellular_component	peptidoglycan-based cell wall
OA	0016740	molecular_function	transferase activity
OA	0016779	molecular_function	nucleotidyltransferase activity
OA	0034062	molecular_function	5'-3' RNA polymerase activity
OA	0046872	molecular_function	metal ion binding
P	0000287	molecular_function	magnesium ion binding
P	0000428	cellular_component	DNA-directed RNA polymerase complex
P	0003677	molecular_function	DNA binding
P	0003899	molecular_function	DNA-directed RNA polymerase activity
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0006351	biological_process	DNA-templated transcription
P	0008270	molecular_function	zinc ion binding
P	0009274	cellular_component	peptidoglycan-based cell wall
P	0016740	molecular_function	transferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0034062	molecular_function	5'-3' RNA polymerase activity
P	0046872	molecular_function	metal ion binding
PA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
PA	0000428	cellular_component	DNA-directed RNA polymerase complex
PA	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
PA	0003677	molecular_function	DNA binding
PA	0003899	molecular_function	DNA-directed RNA polymerase activity
PA	0005829	cellular_component	cytosol
PA	0006351	biological_process	DNA-templated transcription
PA	0006352	biological_process	DNA-templated transcription initiation
PA	0009274	cellular_component	peptidoglycan-based cell wall
PA	0016740	molecular_function	transferase activity
PA	0016779	molecular_function	nucleotidyltransferase activity
PA	0034062	molecular_function	5'-3' RNA polymerase activity
Q	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
Q	0000428	cellular_component	DNA-directed RNA polymerase complex
Q	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
Q	0003677	molecular_function	DNA binding
Q	0003899	molecular_function	DNA-directed RNA polymerase activity
Q	0005829	cellular_component	cytosol
Q	0006351	biological_process	DNA-templated transcription
Q	0006352	biological_process	DNA-templated transcription initiation
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0016740	molecular_function	transferase activity
Q	0016779	molecular_function	nucleotidyltransferase activity
Q	0034062	molecular_function	5'-3' RNA polymerase activity
QA	0000976	molecular_function	transcription cis-regulatory region binding
QA	0001666	biological_process	response to hypoxia
QA	0003677	molecular_function	DNA binding
QA	0003700	molecular_function	DNA-binding transcription factor activity
QA	0003899	molecular_function	DNA-directed RNA polymerase activity
QA	0005515	molecular_function	protein binding
QA	0005829	cellular_component	cytosol
QA	0005886	cellular_component	plasma membrane
QA	0006351	biological_process	DNA-templated transcription
QA	0006352	biological_process	DNA-templated transcription initiation
QA	0006355	biological_process	regulation of DNA-templated transcription
QA	0009408	biological_process	response to heat
QA	0009410	biological_process	response to xenobiotic stimulus
QA	0016987	molecular_function	sigma factor activity
QA	0043175	molecular_function	RNA polymerase core enzyme binding
QA	0045893	biological_process	positive regulation of DNA-templated transcription
QA	1903865	cellular_component	sigma factor antagonist complex
QA	2000142	biological_process	regulation of DNA-templated transcription initiation
R	0000976	molecular_function	transcription cis-regulatory region binding
R	0001666	biological_process	response to hypoxia
R	0003677	molecular_function	DNA binding
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0003899	molecular_function	DNA-directed RNA polymerase activity
R	0005515	molecular_function	protein binding
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006351	biological_process	DNA-templated transcription
R	0006352	biological_process	DNA-templated transcription initiation
R	0006355	biological_process	regulation of DNA-templated transcription
R	0009408	biological_process	response to heat
R	0009410	biological_process	response to xenobiotic stimulus
R	0016987	molecular_function	sigma factor activity
R	0043175	molecular_function	RNA polymerase core enzyme binding
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	1903865	cellular_component	sigma factor antagonist complex
R	2000142	biological_process	regulation of DNA-templated transcription initiation
RA	0000428	cellular_component	DNA-directed RNA polymerase complex
RA	0003677	molecular_function	DNA binding
RA	0003899	molecular_function	DNA-directed RNA polymerase activity
RA	0005737	cellular_component	cytoplasm
RA	0005829	cellular_component	cytosol
RA	0005886	cellular_component	plasma membrane
RA	0006351	biological_process	DNA-templated transcription
RA	0009274	cellular_component	peptidoglycan-based cell wall
RA	0016740	molecular_function	transferase activity
RA	0016779	molecular_function	nucleotidyltransferase activity
RA	0034062	molecular_function	5'-3' RNA polymerase activity
RA	0046983	molecular_function	protein dimerization activity
S	0000428	cellular_component	DNA-directed RNA polymerase complex
S	0003677	molecular_function	DNA binding
S	0003899	molecular_function	DNA-directed RNA polymerase activity
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005886	cellular_component	plasma membrane
S	0006351	biological_process	DNA-templated transcription
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0016740	molecular_function	transferase activity
S	0016779	molecular_function	nucleotidyltransferase activity
S	0034062	molecular_function	5'-3' RNA polymerase activity
S	0046983	molecular_function	protein dimerization activity
SA	0000428	cellular_component	DNA-directed RNA polymerase complex
SA	0003677	molecular_function	DNA binding
SA	0003899	molecular_function	DNA-directed RNA polymerase activity
SA	0005737	cellular_component	cytoplasm
SA	0005829	cellular_component	cytosol
SA	0005886	cellular_component	plasma membrane
SA	0006351	biological_process	DNA-templated transcription
SA	0009274	cellular_component	peptidoglycan-based cell wall
SA	0016740	molecular_function	transferase activity
SA	0016779	molecular_function	nucleotidyltransferase activity
SA	0034062	molecular_function	5'-3' RNA polymerase activity
SA	0046983	molecular_function	protein dimerization activity
T	0000428	cellular_component	DNA-directed RNA polymerase complex
T	0003677	molecular_function	DNA binding
T	0003899	molecular_function	DNA-directed RNA polymerase activity
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005886	cellular_component	plasma membrane
T	0006351	biological_process	DNA-templated transcription
T	0009274	cellular_component	peptidoglycan-based cell wall
T	0016740	molecular_function	transferase activity
T	0016779	molecular_function	nucleotidyltransferase activity
T	0034062	molecular_function	5'-3' RNA polymerase activity
T	0046983	molecular_function	protein dimerization activity
TA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
TA	0000428	cellular_component	DNA-directed RNA polymerase complex
TA	0003677	molecular_function	DNA binding
TA	0003899	molecular_function	DNA-directed RNA polymerase activity
TA	0005515	molecular_function	protein binding
TA	0005829	cellular_component	cytosol
TA	0005886	cellular_component	plasma membrane
TA	0006351	biological_process	DNA-templated transcription
TA	0006352	biological_process	DNA-templated transcription initiation
TA	0006354	biological_process	DNA-templated transcription elongation
TA	0009274	cellular_component	peptidoglycan-based cell wall
TA	0016740	molecular_function	transferase activity
TA	0016779	molecular_function	nucleotidyltransferase activity
TA	0032549	molecular_function	ribonucleoside binding
TA	0034062	molecular_function	5'-3' RNA polymerase activity
TA	0046677	biological_process	response to antibiotic
UA	0000287	molecular_function	magnesium ion binding
UA	0000428	cellular_component	DNA-directed RNA polymerase complex
UA	0003677	molecular_function	DNA binding
UA	0003899	molecular_function	DNA-directed RNA polymerase activity
UA	0005829	cellular_component	cytosol
UA	0005886	cellular_component	plasma membrane
UA	0006351	biological_process	DNA-templated transcription
UA	0008270	molecular_function	zinc ion binding
UA	0009274	cellular_component	peptidoglycan-based cell wall
UA	0016740	molecular_function	transferase activity
UA	0016779	molecular_function	nucleotidyltransferase activity
UA	0034062	molecular_function	5'-3' RNA polymerase activity
UA	0046872	molecular_function	metal ion binding
V	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
V	0000428	cellular_component	DNA-directed RNA polymerase complex
V	0003677	molecular_function	DNA binding
V	0003899	molecular_function	DNA-directed RNA polymerase activity
V	0005515	molecular_function	protein binding
V	0005829	cellular_component	cytosol
V	0005886	cellular_component	plasma membrane
V	0006351	biological_process	DNA-templated transcription
V	0006352	biological_process	DNA-templated transcription initiation
V	0006354	biological_process	DNA-templated transcription elongation
V	0009274	cellular_component	peptidoglycan-based cell wall
V	0016740	molecular_function	transferase activity
V	0016779	molecular_function	nucleotidyltransferase activity
V	0032549	molecular_function	ribonucleoside binding
V	0034062	molecular_function	5'-3' RNA polymerase activity
V	0046677	biological_process	response to antibiotic
VA	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
VA	0000428	cellular_component	DNA-directed RNA polymerase complex
VA	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
VA	0003677	molecular_function	DNA binding
VA	0003899	molecular_function	DNA-directed RNA polymerase activity
VA	0005829	cellular_component	cytosol
VA	0006351	biological_process	DNA-templated transcription
VA	0006352	biological_process	DNA-templated transcription initiation
VA	0009274	cellular_component	peptidoglycan-based cell wall
VA	0016740	molecular_function	transferase activity
VA	0016779	molecular_function	nucleotidyltransferase activity
VA	0034062	molecular_function	5'-3' RNA polymerase activity
W	0000287	molecular_function	magnesium ion binding
W	0000428	cellular_component	DNA-directed RNA polymerase complex
W	0003677	molecular_function	DNA binding
W	0003899	molecular_function	DNA-directed RNA polymerase activity
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006351	biological_process	DNA-templated transcription
W	0008270	molecular_function	zinc ion binding
W	0009274	cellular_component	peptidoglycan-based cell wall
W	0016740	molecular_function	transferase activity
W	0016779	molecular_function	nucleotidyltransferase activity
W	0034062	molecular_function	5'-3' RNA polymerase activity
W	0046872	molecular_function	metal ion binding
WA	0000976	molecular_function	transcription cis-regulatory region binding
WA	0001666	biological_process	response to hypoxia
WA	0003677	molecular_function	DNA binding
WA	0003700	molecular_function	DNA-binding transcription factor activity
WA	0003899	molecular_function	DNA-directed RNA polymerase activity
WA	0005515	molecular_function	protein binding
WA	0005829	cellular_component	cytosol
WA	0005886	cellular_component	plasma membrane
WA	0006351	biological_process	DNA-templated transcription
WA	0006352	biological_process	DNA-templated transcription initiation
WA	0006355	biological_process	regulation of DNA-templated transcription
WA	0009408	biological_process	response to heat
WA	0009410	biological_process	response to xenobiotic stimulus
WA	0016987	molecular_function	sigma factor activity
WA	0043175	molecular_function	RNA polymerase core enzyme binding
WA	0045893	biological_process	positive regulation of DNA-templated transcription
WA	1903865	cellular_component	sigma factor antagonist complex
WA	2000142	biological_process	regulation of DNA-templated transcription initiation
X	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
X	0000428	cellular_component	DNA-directed RNA polymerase complex
X	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
X	0003677	molecular_function	DNA binding
X	0003899	molecular_function	DNA-directed RNA polymerase activity
X	0005829	cellular_component	cytosol
X	0006351	biological_process	DNA-templated transcription
X	0006352	biological_process	DNA-templated transcription initiation
X	0009274	cellular_component	peptidoglycan-based cell wall
X	0016740	molecular_function	transferase activity
X	0016779	molecular_function	nucleotidyltransferase activity
X	0034062	molecular_function	5'-3' RNA polymerase activity
Y	0000976	molecular_function	transcription cis-regulatory region binding
Y	0001666	biological_process	response to hypoxia
Y	0003677	molecular_function	DNA binding
Y	0003700	molecular_function	DNA-binding transcription factor activity
Y	0003899	molecular_function	DNA-directed RNA polymerase activity
Y	0005515	molecular_function	protein binding
Y	0005829	cellular_component	cytosol
Y	0005886	cellular_component	plasma membrane
Y	0006351	biological_process	DNA-templated transcription
Y	0006352	biological_process	DNA-templated transcription initiation
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0009408	biological_process	response to heat
Y	0009410	biological_process	response to xenobiotic stimulus
Y	0016987	molecular_function	sigma factor activity
Y	0043175	molecular_function	RNA polymerase core enzyme binding
Y	0045893	biological_process	positive regulation of DNA-templated transcription
Y	1903865	cellular_component	sigma factor antagonist complex
Y	2000142	biological_process	regulation of DNA-templated transcription initiation
Z	0000428	cellular_component	DNA-directed RNA polymerase complex
Z	0003677	molecular_function	DNA binding
Z	0003899	molecular_function	DNA-directed RNA polymerase activity
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005886	cellular_component	plasma membrane
Z	0006351	biological_process	DNA-templated transcription
Z	0009274	cellular_component	peptidoglycan-based cell wall
Z	0016740	molecular_function	transferase activity
Z	0016779	molecular_function	nucleotidyltransferase activity
Z	0034062	molecular_function	5'-3' RNA polymerase activity
Z	0046983	molecular_function	protein dimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00715
Number of Residues	14
Details	SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAM

Chain	Residue	Details
EA	ASP114-MET127

---

site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TldQIGklfgLSrerVrQIErdvMskL

Chain	Residue	Details
EA	THR283-LEU309

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL

Chain	Residue	Details
EA	LEU90-LEU97

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV

Chain	Residue	Details
BA	GLY882-VAL894

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	272
Details	Region: {"description":"Sigma-70 factor domain-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Motif: {"description":"Polymerase core binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---