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7L7B	Clostridioides difficile RNAP with fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. Deposit date: 2020-12-28 Release date: 2022-02-02 Last modified: 2022-05-04 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
7MKD	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKE	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKI	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.75 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7N4E	Escherichia coli sigma 70-dependent paused transcription elongation complex Descriptor: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Su, M, Ebright, R.H. Deposit date: 2021-06-04 Release date: 2022-06-15 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
7P5X	Mycobacterial RNAP with transcriptional activator PafBC Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. Deposit date: 2021-07-15 Release date: 2021-12-22 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
7PP4	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-09-13 Release date: 2022-09-21 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Biorxiv, 2022
7Q4U	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-02 Release date: 2022-11-16 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (4.39 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-03 Release date: 2022-11-16 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7RDQ	Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA Descriptor: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-07-10 Release date: 2022-02-02 Last modified: 2022-02-09 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7SZJ	Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex Descriptor: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2021-11-28 Release date: 2022-07-13 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.11 Å) Cite: Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex Descriptor: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2021-11-28 Release date: 2022-07-13 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7U22	Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 Descriptor: (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Molodtsov, V, Ebright, R.H. Deposit date: 2022-02-22 Release date: 2022-10-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.87 Å) Cite: Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61, 2022
7UBM	Transcription antitermination complex: "pre-engaged" Qlambda-loading complex Descriptor: Antitermination protein Q, DNA (52-MER), DNA (53-MER), ... Authors: Yin, Z, Ebright, R.H. Deposit date: 2022-03-15 Release date: 2022-09-28 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
7UBN	Transcription antitermination complex: NusA-containing "engaged" Qlambda-loading complex Descriptor: Antitermination protein, DNA (52-MER), DNA (53-MER), ... Authors: Yin, Z, Ebright, R.H. Deposit date: 2022-03-15 Release date: 2022-09-28 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
7VF9	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2021-09-10 Release date: 2022-07-27 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (4.04 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7VPD	Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with one Zur dimers Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2021-10-15 Release date: 2022-08-03 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (3.77 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7VPZ	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2021-10-18 Release date: 2022-08-03 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (4.14 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7VWY	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y. Deposit date: 2021-11-12 Release date: 2022-06-08 Last modified: 2023-06-07 Method: ELECTRON MICROSCOPY (4.57 Å) Cite: Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
7VWZ	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y, Shi, J. Deposit date: 2021-11-12 Release date: 2022-06-08 Last modified: 2022-06-22 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
7W5W	Cryo-EM structure of SoxS-dependent transcription activation complex with micF promoter DNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y. Deposit date: 2021-11-30 Release date: 2022-10-26 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (4.55 Å) Cite: Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. Nucleic Acids Res., 50, 2022

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