PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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3VZR	Crystal structure of T173S mutant of PhaB from Ralstonia eutropha 分子名称: Acetoacetyl-CoA reductase 著者 Ikeda, K, Tanaka, Y, Tanaka, I, Yao, M. 登録日 2012-10-15 公開日 2013-08-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics Appl.Environ.Microbiol., 79, 2013
7ONU	Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-Tyr 分子名称: 3-hydroxyacyl-CoA dehydrogenase type-2, MAGNESIUM ION, Mitochondrial Precursor tRNA-Tyr, ... 著者 Bhatta, A, Dienemann, C, Cramer, P, Hillen, H.S. 登録日 2021-05-26 公開日 2021-08-11 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis of RNA processing by human mitochondrial RNase P. Nat.Struct.Mol.Biol., 28, 2021
3V2H	The crystal structure of D-beta-hydroxybutyrate dehydrogenase from Sinorhizobium meliloti 分子名称: D-beta-hydroxybutyrate dehydrogenase 著者 Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2011-12-12 公開日 2011-12-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The crystal structure of D-beta-hydroxybutyrate dehydrogenase from Sinorhizobium meliloti To be Published
1EQU	TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+ 分子名称: EQUILIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (ESTRADIOL 17 BETA-DEHYDROGENASE 1) 著者 Sawicki, M.W, Erman, M, Puranen, T, Vihko, P, Ghosh, D. 登録日 1998-12-02 公開日 1999-12-02 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+. Proc.Natl.Acad.Sci.USA, 96, 1999
3VDR	Crystal structure of D-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate D-3-hydroxybutyrate and NAD(+) 分子名称: (3R)-3-hydroxybutanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETOACETIC ACID, ... 著者 Hoque, M.M, Shimizu, S, Juan, E.C.M, Sato, Y, Hossain, M.T, Yamamoto, T, Imamura, S, Amano, H, Suzuki, K, Sekiguchi, T, Tsunoda, M, Takenaka, A. 登録日 2012-01-06 公開日 2012-02-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of D-3-hydroxybutyrate dehydrogenase prepared in the presence of the substrate D-3-hydroxybutyrate and NAD+. Acta Crystallogr.,Sect.F, 65, 2009
3EY4	Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model 分子名称: (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one, 11-beta-Hydroxysteroid Dehydrogenase 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Zhang, J.D, Jordan, S.R, Li, V. 登録日 2008-10-17 公開日 2008-11-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model To be Published, 2008
1Y5R	The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone 分子名称: CORTICOSTERONE, Corticosteroid 11-beta-dehydrogenase, isozyme 1, ... 著者 Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S. 登録日 2004-12-02 公開日 2005-05-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes Biochemistry, 44, 2005
1FDV	HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH NAD+ 分子名称: 17-BETA-HYDROXYSTEROID DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Mazza, C, Breton, R, Housset, D, Fontecilla-Camps, J.-C. 登録日 1998-01-15 公開日 1998-05-27 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 273, 1998
2IRW	Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor 分子名称: (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Longenecker, K.L, Patel, J.R, Russell, J, Qin, W. 登録日 2006-10-16 公開日 2007-01-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation. Bioorg.Med.Chem.Lett., 17, 2007
7JK9	Helical filaments of plant light-dependent protochlorophyllide oxidoreductase (LPOR) bound to NADPH, Pchlide, and membrane 分子名称: 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Protochlorophyllide, ... 著者 Nguyen, H.C, Gabruk, M, Frost, A. 登録日 2020-07-28 公開日 2021-03-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. Nat.Plants, 7, 2021
6K8W	Crystal structure of N-domain with NADP of baterial malonyl-CoA reductase 分子名称: NAD-dependent epimerase/dehydratase:Short-chain dehydrogenase/reductase SDR, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION 著者 Kim, S, Kim, K.-J. 登録日 2019-06-13 公開日 2020-03-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 Structural insight into bi-functional malonyl-CoA reductase. Environ.Microbiol., 22, 2020
4YYZ	11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Branden, G, Boden, C, Ogg, D. 登録日 2015-03-24 公開日 2016-02-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design of pyrozolo-pyrimidines as 11beta-HSD1 inhibitors through optimisation of molecular electrostatic potential. Medchemcomm, 6, 2016
8JAT	Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans 分子名称: 3-ketodihydrosphingosine reductase TSC10, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Zhao, P, Kuang, Z. 登録日 2023-05-07 公開日 2023-06-21 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans. Biochem.Biophys.Res.Commun., 670, 2023
8FD8	human 15-PGDH with NADH bound 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 著者 Huang, W, Taylor, D. 登録日 2022-12-02 公開日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14, 2023
8HI4	Cryo-EM structure of the bi-functional malonyl-CoA reductase from Roseiflexus castenholzii 分子名称: Short-chain dehydrogenase/reductase SDR 著者 Zhang, X, Xu, X, Xin, J. 登録日 2022-11-18 公開日 2023-05-31 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii. Mbio, 14, 2023
8HJW	Bi-functional malonyl-CoA reductuase from Chloroflexus aurantiacus 分子名称: Short-chain dehydrogenase/reductase SDR 著者 Ahn, J.W, Kim, S. 登録日 2022-11-24 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
2CDH	ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION. 分子名称: DEHYDRATASE, ENOYL REDUCTASE, KETOACYL REDUCTASE, ... 著者 Jenni, S, Leibundgut, M, Maier, T, Ban, N. 登録日 2006-01-24 公開日 2006-03-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (4.2 Å) 主引用文献 Architecture of a Fungal Fatty Acid Synthase at 5 A Resolution. Science, 311, 2006

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