4YYZ

11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR

Summary for 4YYZ

• Entry DOI: 10.2210/pdb4yyz/pdb
• Related: 4C7J 4C7K
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
• Functional Keywords: dehydrogenase inhibitor, bhsd, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• Total number of polymer chains: 2
• Total formula weight: 58935.62

Authors

Branden, G.,Boden, C.,Ogg, D. (deposition date: 2015-03-24, release date: 2016-02-03)

• Primary citation: Robb, G.R.,Boyd, S.,Davies, C.D.,Dossiter, A.G.,Goldberg, F.W.,Kemmitt, P.D.,Scott, J.S.,Swales, J.G.; Design of pyrozolo-pyrimidines as 11beta-HSD1 inhibitors through optimisation of molecular electrostatic potential.; Medchemcomm, 6:926-934, 2016; DOI: 10.1039/C5MD00043B

Experimental method

X-RAY DIFFRACTION (3.2 Å)