4YYZ
11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 259 | 28384.0 | 2 | UniProt (P28845) Pfam (PF00106) In PDB | Homo sapiens (Human) | 11-beta-hydroxysteroid dehydrogenase 1,11-beta-HSD1 |
| 2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | A, B | N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 340.4 | 2 | Chemie (4JX) |
Sequence modifications
A, B: 26 - 284 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Leu 179 | Met 179 | conflict |
| Arg 262 | Leu 262 | conflict |
| Ser 272 | Cys 272 | conflict |
| Glu 278 | Phe 278 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56768.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2167.6 | |
| All* | Total formula weight | 58935.6 |
