1Y5R

The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone

Summary for 1Y5R

• Entry DOI: 10.2210/pdb1y5r/pdb
• Related: 1Y5M
• Descriptor: Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CORTICOSTERONE (3 entities in total)
• Functional Keywords: corticosterone bound, oxidoreductase
• Biological source: Mus musculus (house mouse)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P50172
• Total number of polymer chains: 2
• Total formula weight: 63355.12

Authors

Zhang, J.,Osslund, T.D.,Plant, M.H.,Clogston, C.L.,Nybo, R.E.,Xiong, F.,Delaney, J.M.,Jordan, S. (deposition date: 2004-12-02, release date: 2005-05-17, Last modification date: 2024-02-14)

• Primary citation: Zhang, J.,Osslund, T.D.,Plant, M.H.,Clogston, C.L.,Nybo, R.E.,Xiong, F.,Delaney, J.M.,Jordan, S.; Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes; Biochemistry, 44:6948-6957, 2005; PubMed: 15865440; DOI: 10.1021/bi047599q

Experimental method

X-RAY DIFFRACTION (3 Å)