1Y5R

The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	polymer	276	30585.7	2	UniProt (P50172) Pfam (PF00106)	Mus musculus (house mouse)	11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1, 11beta- HSD1A
2	C, E (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	D, F (A, B)	CORTICOSTERONE	non-polymer		346.5	2	Chemie (C0R) PubChem (16758819) PubChem (23955860) PubChem (24867266) PubChem (44308367) PubChem (24939323) PubChem (71211089) PubChem (51414212) PubChem (53314896) PubChem (53393626) PubChem (56615189) PubChem (56622343) PubChem (256277) PubChem (60111547) PubChem (439739) PubChem (439858) PubChem (667425) PubChem (77847229) PubChem (5753) PubChem (6400915) PubChem (6603769) PubChem (117072366) PubChem (10088985) PubChem (10088986) PubChem (12358831) PubChem (139322712) PubChem (124335856) PubChem (124761752) PubChem (124761753) PubChem (124907328) PubChem (129360099) PubChem (132012243) PubChem (132123953) PubChem (134424963) PubChem (134425001) PubChem (134425135) PubChem (157049267) PubChem (163841308) PubChem (166480827) PubChem (166480843) PubChem (173508841)

Sequence modifications

A, B: 24 - 292 (UniProt: P50172)

PDB	External Database	Details
Met 17	-	cloning artifact
His 18	-	cloning artifact
His 19	-	cloning artifact
His 20	-	cloning artifact
His 21	-	cloning artifact
His 22	-	cloning artifact
His 23	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61171.4
Non-Polymers*	Number of molecules	4
	Total formula weight	2183.8
All*	Total formula weight	63355.1

*Water molecules are not included.