8FD8

human 15-PGDH with NADH bound

Summary for 8FD8

• Entry DOI: 10.2210/pdb8fd8/pdb
• EMDB information: 29005
• Descriptor: 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE (2 entities in total)
• Functional Keywords: dehydrogenase, inhibitor, oxidoreductase, oxidoreductase-inhibitor complex
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 57102.99

Authors

Huang, W.,Taylor, D. (deposition date: 2022-12-02, release date: 2023-03-08)

• Primary citation: Huang, W.,Li, H.,Kiselar, J.,Fink, S.P.,Regmi, S.,Day, A.,Yuan, Y.,Chance, M.,Ready, J.M.,Markowitz, S.D.,Taylor, D.J.; Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.; Nat Commun, 14:784-784, 2023; PubMed: 36774348; DOI: 10.1038/s41467-023-36463-7

Experimental method

ELECTRON MICROSCOPY (3.3 Å)