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6Y5Q
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BU of 6y5q by Molmil
human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-25
Release date:2020-06-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
6Y53
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human 17S U2 snRNP low resolution part
Descriptor: HIV Tat-specific factor 1, Probable ATP-dependent RNA helicase DDX46, Small nuclear ribonucleoprotein E, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-24
Release date:2020-06-17
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
6Y50
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BU of 6y50 by Molmil
5'domain of human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-24
Release date:2020-07-01
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
6XYW
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BU of 6xyw by Molmil
Structure of the plant mitochondrial ribosome
Descriptor: 28S ribosomal S34 protein, 3-hydroxyisobutyryl-CoA hydrolase-like protein 2, mitochondrial, ...
Authors:Soufari, H, Waltz, F, Bochler, A, Giege, P, Hashem, Y.
Deposit date:2020-01-31
Release date:2020-04-15
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (3.86 Å)
Cite:Cryo-EM structure of the RNA-rich plant mitochondrial ribosome.
Nat.Plants, 6, 2020
6XLX
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BU of 6xlx by Molmil
Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
6XLW
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Crystal structure of U2AF65 bound to AdML splice site sequence
Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ...
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
6XLV
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Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
6XH3
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BU of 6xh3 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.3
Descriptor: TAR BINDING PROTEIN TBP 6.3, TRANS-ACTIVATION RESPONSE ELEMENT
Authors:Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
Deposit date:2020-06-18
Release date:2020-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.353 Å)
Cite:Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6XH2
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BU of 6xh2 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM 6.6
Descriptor: TAR-BINDING PROTEIN 6.6, TRANS-ACTIVATION RESPONSE ELEMENT
Authors:Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
Deposit date:2020-06-18
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6XH1
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BU of 6xh1 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.7 mutant
Descriptor: TAR binding protein mutant 6.7 Q48R/T50R, TRANS-ACTIVATION RESPONSE ELEMENT
Authors:Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
Deposit date:2020-06-18
Release date:2020-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6XH0
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BU of 6xh0 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.9
Descriptor: MAGNESIUM ION, TAR binding protein 6.9, TRANS-ACTIVATION RESPONSE ELEMENT
Authors:Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
Deposit date:2020-06-18
Release date:2020-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6X89
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BU of 6x89 by Molmil
Vigna radiata mitochondrial complex I*
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Letts, J.A, Maldonado, M, Padavannil, A, Zhou, L, Guo, F.
Deposit date:2020-06-01
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic structure of a mitochondrial complex I intermediate from vascular plants.
Elife, 9, 2020
6WMZ
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BU of 6wmz by Molmil
Crystal structure of human SFPQ/NONO complex
Descriptor: Non-POU domain-containing octamer-binding protein, SULFATE ION, Splicing factor, ...
Authors:Lee, M, Bond, C.S.
Deposit date:2020-04-22
Release date:2021-04-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure analysis of human SFPQ/NONO complex
To Be Published
6UE5
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BU of 6ue5 by Molmil
Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Descriptor: 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ...
Authors:Knapp, M.S, Shu, W, Xie, L, Bussiere, D.E.
Deposit date:2019-09-20
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat.Chem.Biol., 16, 2020
6UD7
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BU of 6ud7 by Molmil
Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam
Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1,DNA damage-binding protein 1, ...
Authors:Bussiere, D.E, Shu, W, Xie, L, Knapp, M.
Deposit date:2019-09-18
Release date:2019-12-18
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat.Chem.Biol., 16, 2020
6TZE
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BU of 6tze by Molmil
Human CstF-64 RRM mutant - D50A
Descriptor: Cleavage stimulation factor subunit 2
Authors:Latham, M.P, Masoumzadeh, E.
Deposit date:2019-08-12
Release date:2020-08-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3' end processing is associated with intellectual disability in humans.
Nucleic Acids Res., 48, 2020
6TR0
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BU of 6tr0 by Molmil
Solution structure of U2AF2 RRM1,2
Descriptor: Splicing factor U2AF 65 kDa subunit
Authors:Kang, H.-S, Sattler, M.
Deposit date:2019-12-17
Release date:2020-05-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
Proc.Natl.Acad.Sci.USA, 117, 2020
6SXW
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BU of 6sxw by Molmil
Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
Descriptor: SULFATE ION, Zinc finger protein 638
Authors:Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-09-26
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
To Be Published
6SR7
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BU of 6sr7 by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/K98W
Descriptor: SULFATE ION, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-05
Release date:2020-05-13
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQV
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BU of 6sqv by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/R70W
Descriptor: SULFATE ION, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQT
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BU of 6sqt by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQQ
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Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant in complex with RNA obtained by soaking
Descriptor: MAGNESIUM ION, RNA hairpin, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SQN
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BU of 6sqn by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant co-crystallized with RNA
Descriptor: RNA hairpin, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
6SNJ
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BU of 6snj by Molmil
Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snRNA stem loop III
Descriptor: RNA-binding protein FUS, U1 snRNA stem loop III, RNA (28-MER)
Authors:Campagne, S, Allain, F.H.
Deposit date:2019-08-26
Release date:2020-10-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Nat Commun, 11, 2020
6SJ7
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BU of 6sj7 by Molmil
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ...
Authors:Srinivas, H.
Deposit date:2019-08-12
Release date:2019-12-18
Last modified:2019-12-25
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat.Chem.Biol., 16, 2020

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