6UE5
Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Summary for 6UE5
Entry DOI | 10.2210/pdb6ue5/pdb |
Related | 6UD7 |
Descriptor | DDB1- and CUL4-associated factor 15, DNA damage-binding protein 1,DNA damage-binding protein 1, RBM39, ... (7 entities in total) |
Functional Keywords | e3 ligase, neosubstrate, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 181152.38 |
Authors | Knapp, M.S.,Shu, W.,Xie, L.,Bussiere, D.E. (deposition date: 2019-09-20, release date: 2019-12-18, Last modification date: 2023-10-11) |
Primary citation | Bussiere, D.E.,Xie, L.,Srinivas, H.,Shu, W.,Burke, A.,Be, C.,Zhao, J.,Godbole, A.,King, D.,Karki, R.G.,Hornak, V.,Xu, F.,Cobb, J.,Carte, N.,Frank, A.O.,Frommlet, A.,Graff, P.,Knapp, M.,Fazal, A.,Okram, B.,Jiang, S.,Michellys, P.Y.,Beckwith, R.,Voshol, H.,Wiesmann, C.,Solomon, J.M.,Paulk, J. Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16:15-23, 2020 Cited by PubMed: 31819272DOI: 10.1038/s41589-019-0411-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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