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6UE5

Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide

Summary for 6UE5
Entry DOI10.2210/pdb6ue5/pdb
Related6UD7
DescriptorDDB1- and CUL4-associated factor 15, DNA damage-binding protein 1,DNA damage-binding protein 1, RBM39, ... (7 entities in total)
Functional Keywordse3 ligase, neosubstrate, ligase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight181152.38
Authors
Knapp, M.S.,Shu, W.,Xie, L.,Bussiere, D.E. (deposition date: 2019-09-20, release date: 2019-12-18, Last modification date: 2023-10-11)
Primary citationBussiere, D.E.,Xie, L.,Srinivas, H.,Shu, W.,Burke, A.,Be, C.,Zhao, J.,Godbole, A.,King, D.,Karki, R.G.,Hornak, V.,Xu, F.,Cobb, J.,Carte, N.,Frank, A.O.,Frommlet, A.,Graff, P.,Knapp, M.,Fazal, A.,Okram, B.,Jiang, S.,Michellys, P.Y.,Beckwith, R.,Voshol, H.,Wiesmann, C.,Solomon, J.M.,Paulk, J.
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat.Chem.Biol., 16:15-23, 2020
Cited by
PubMed: 31819272
DOI: 10.1038/s41589-019-0411-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.61 Å)
Structure validation

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