6UD7

Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam

Summary for 6UD7

• Entry DOI: 10.2210/pdb6ud7/pdb
• Descriptor: DDB1- and CUL4-associated factor 15, DNA damage-binding protein 1,DNA damage-binding protein 1, RNA-binding motif protein 39, ... (7 entities in total)
• Functional Keywords: e3 ligase, neosubstrate, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 181289.92

Authors

Bussiere, D.E.,Shu, W.,Xie, L.,Knapp, M. (deposition date: 2019-09-18, release date: 2019-12-18, Last modification date: 2020-01-22)

• Primary citation: Bussiere, D.E.,Xie, L.,Srinivas, H.,Shu, W.,Burke, A.,Be, C.,Zhao, J.,Godbole, A.,King, D.,Karki, R.G.,Hornak, V.,Xu, F.,Cobb, J.,Carte, N.,Frank, A.O.,Frommlet, A.,Graff, P.,Knapp, M.,Fazal, A.,Okram, B.,Jiang, S.,Michellys, P.Y.,Beckwith, R.,Voshol, H.,Wiesmann, C.,Solomon, J.M.,Paulk, J.; Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.; Nat.Chem.Biol., 16:15-23, 2020; PubMed: 31819272; DOI: 10.1038/s41589-019-0411-6

Experimental method

X-RAY DIFFRACTION (2.3 Å)