6UE5
Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DDB1- and CUL4-associated factor 15 | polymer | 601 | 66563.3 | 1 | UniProt (Q66K64) Pfam (PF14939) | Homo sapiens (Human) | |
| 2 | B (B) | DNA damage-binding protein 1,DNA damage-binding protein 1 | polymer | 836 | 93347.1 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe,DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 3 | C (C) | RBM39 | polymer | 81 | 9085.4 | 1 | UniProt (Q7Z3L0) Pfam (PF00076) UniProt (by SIFTS) (Q14498) | Homo sapiens (Human) | |
| 4 | D (D) | DET1- and DDB1-associated protein 1 | polymer | 101 | 11724.1 | 1 | UniProt (Q9BW61) Pfam (PF10172) | Homo sapiens (Human) | Placenta cross-immune reaction antigen 1,PCIA-1 |
| 5 | E (A) | 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide | non-polymer | 340.4 | 1 | Chemie (Q5J) | |||
| 6 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 515 | Chemie (HOH) |
Sequence modifications
A: 2 - 600 (UniProt: Q66K64)
B: 1 - 395 (UniProt: Q16531)
B: 706 - 1140 (UniProt: Q16531)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
B: 706 - 1140 (UniProt: Q16531)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | linker |
| Asn 701 | - | linker |
| Gly 702 | - | linker |
| Asn 703 | - | linker |
| Ser 704 | - | linker |
| Gly 705 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 180719.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 432.5 | |
| All* | Total formula weight | 181152.4 |
