6UE5
Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0002376 | biological_process | immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| A | 0031465 | cellular_component | Cul4B-RING E3 ubiquitin ligase complex |
| A | 0032814 | biological_process | regulation of natural killer cell activation |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005634 | cellular_component | nucleus |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0006397 | biological_process | mRNA processing |
| D | 0000209 | biological_process | protein polyubiquitination |
| D | 0005515 | molecular_function | protein binding |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0016567 | biological_process | protein ubiquitination |
| D | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| D | 0031465 | cellular_component | Cul4B-RING E3 ubiquitin ligase complex |
| D | 0032434 | biological_process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| D | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| D | 0032814 | biological_process | regulation of natural killer cell activation |
| D | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue Q5J A 701 |
| Chain | Residue |
| A | PHE231 |
| C | HOH401 |
| A | GLN232 |
| A | PRO233 |
| A | ALA234 |
| A | PHE235 |
| A | ARG552 |
| A | LEU563 |
| C | ASP264 |
| C | MET265 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 1201 |
| Chain | Residue |
| B | GLU875 |
| B | PHE876 |
| B | ASN877 |
| B | THR916 |
| B | GLY918 |
| B | HOH1322 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819272","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819272","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 343 |
| Details | Region: {"description":"WD repeat beta-propeller A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 9 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
