6XLV
Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
Summary for 6XLV
Entry DOI | 10.2210/pdb6xlv/pdb |
Descriptor | Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3') (3 entities in total) |
Functional Keywords | protein-rna complex, rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna complex, rna binding protein, rna binding protein-splicing complex, rna binding protein/splicing |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 24701.70 |
Authors | Maji, D.,Jenkins, J.L.,Kielkopf, C.L. (deposition date: 2020-06-29, release date: 2020-10-07, Last modification date: 2023-10-18) |
Primary citation | Maji, D.,Glasser, E.,Henderson, S.,Galardi, J.,Pulvino, M.J.,Jenkins, J.L.,Kielkopf, C.L. Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295:17148-17157, 2020 Cited by PubMed: 33020180DOI: 10.1074/jbc.RA120.015339 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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