6XLV

Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site

Summary for 6XLV

• Entry DOI: 10.2210/pdb6xlv/pdb
• Descriptor: Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3') (3 entities in total)
• Functional Keywords: protein-rna complex, rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna complex, rna binding protein, rna binding protein-splicing complex, rna binding protein/splicing
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 24701.70

Authors

Maji, D.,Jenkins, J.L.,Kielkopf, C.L. (deposition date: 2020-06-29, release date: 2020-10-07, Last modification date: 2023-10-18)

• Primary citation: Maji, D.,Glasser, E.,Henderson, S.,Galardi, J.,Pulvino, M.J.,Jenkins, J.L.,Kielkopf, C.L.; Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.; J.Biol.Chem., 295:17148-17157, 2020; PubMed: 33020180; DOI: 10.1074/jbc.RA120.015339

Experimental method

X-RAY DIFFRACTION (1.4 Å)